Woimant F, Lecoz P, Rajzbaum G, Haguenau M, Pépin B
Ann Med Interne (Paris). 1986;137(6):510-3.
Thirty-three patients hospitalized as they presented with cerebral vascular lesions during anticoagulant therapy (25 intracerebral hemorrhages, 7 subdural hematoma, and one ischemia lesion). Frequency of intra-cerebral hemorrhages along with anticoagulant therapy was about 11 p. 100, this of subdural hematoma ranged from 12 to 38 p. 100. Intra-cerebral hemorrhages failed to show any peculiar topography and volume was variable. A predisposing factor thus existed in about 50 p. 100 of cases: high blood pressure or arterial aneurysm. Previous cranial traumatism was only demonstrated in 48 p. 100 patients presenting with a subdural hematoma. Prognosis as for these intracranial hemorrhages might be compared to this of hemorrhagic lesions appearing under other etiologic conditions. Ischemia lesion was secondary to a severe thrombopenia to heparin.
33例患者在抗凝治疗期间因出现脑血管病变而住院(25例脑出血,7例硬膜下血肿,1例缺血性病变)。抗凝治疗期间脑出血的发生率约为11/100,硬膜下血肿的发生率为12/100至38/100。脑出血未显示出任何特殊的部位,出血量也各不相同。约50/100的病例存在诱发因素:高血压或动脉瘤。仅有48/100出现硬膜下血肿的患者有既往颅脑外伤史。这些颅内出血的预后可与其他病因导致的出血性病变的预后相比较。缺血性病变继发于严重的肝素诱导的血小板减少症。