Lucia Umberto, Fino Debora, Deisboeck Thomas S, Grisolia Giulia
Dipartimento Energia "Galileo Ferraris", Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy.
Dipartimento di Scienza Applicata e Tecnologia, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy.
Membranes (Basel). 2023 Nov 30;13(12):895. doi: 10.3390/membranes13120895.
The constructal law is used to improve the analysis of the resonant heat transfer in cancer cells. The result highlights the fundamental role of the volume/area ratio and its role in cancer growth and invasion. Cancer cells seek to increase their surface area to facilitate heat dissipation; as such, the tumour expansion ratio declines as malignant cells start to migrate and the cancer expands locally and systemically. Consequently, we deduce that effective anticancer therapy should be based on the control of some ion transport phenomena in an effort to increase the volume/area ratio. This emphasises restricting the local and systemic spatial expansion of the tumour system and thus gives further credence to the superior role of novel anti-migratory and anti-invasive treatment strategies over conventional anti-proliferative options only.
构造定律被用于改进对癌细胞中谐振热传递的分析。结果突出了体积/面积比的基本作用及其在癌症生长和侵袭中的作用。癌细胞试图增加其表面积以促进散热；因此，随着恶性细胞开始迁移且癌症在局部和全身扩散，肿瘤扩展率会下降。由此，我们推断有效的抗癌治疗应基于对某些离子传输现象的控制，以努力增加体积/面积比。这强调了限制肿瘤系统的局部和全身空间扩展，从而进一步证明了新型抗迁移和抗侵袭治疗策略相对于仅传统抗增殖方案的优越作用。
