Dipartimento Energia "Galileo Ferraris", Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy.
Department of Radiology, Harvard-MIT Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Boston, MA 02129, USA.
Int J Mol Sci. 2023 Feb 7;24(4):3337. doi: 10.3390/ijms24043337.
We present a novel thermodynamic approach to the epigenomics of cancer metabolism. Here, any change in a cancer cell's membrane electric potential is completely irreversible, and as such, cells must consume metabolites to reverse the potential whenever required to maintain cell activity, a process driven by ion fluxes. Moreover, the link between cell proliferation and the membrane's electric potential is for the first time analytically proven using a thermodynamic approach, highlighting how its control is related to inflow and outflow of ions; consequently, a close interaction between environment and cell activity emerges. Lastly, we illustrate the concept by evaluating the Fe2+-flux in the presence of carcinogenesis-promoting mutations of the TET1/2/3 gene family.
我们提出了一种新的热力学方法来研究癌症代谢的表观基因组学。在这里，癌细胞膜电势的任何变化都是完全不可逆的，因此，细胞必须消耗代谢物来逆转电势，只要需要维持细胞活动，这个过程是由离子流驱动的。此外，细胞增殖与膜电势之间的联系首次通过热力学方法得到了分析证明，这突出了其控制与离子的流入和流出之间的关系；因此，环境与细胞活动之间出现了密切的相互作用。最后，我们通过评估 TET1/2/3 基因家族致癌突变存在时的 Fe2+通量来说明这一概念。
