Caterino Chiara, Della Valle Giovanni, Aragosa Federica, Cavalli Stefano, Guccione Jacopo, Lamagna Francesco, Fatone Gerardo
Department of Veterinary Medicine and Animal Production, University of Naples "Federico II", 80137 Naples, Italy.
Vet Sci. 2023 Dec 1;10(12):686. doi: 10.3390/vetsci10120686.
Platelet concentrates (PCs) have become widely used in veterinary and human medicine. The PCs consist mainly of supraphysiological concentrations of platelets and, therefore, growth factors (GFs) which are stored within platelet α-granules. Among PCs, Platelet-Rich Plasma (PRP) is characterised by low-density fibrin. Research on the effect of PCs in cattle has surged in recent years; in particular, evidence has shown the positive use of PRP for treating reproductive problems, in vitro production of bovine embryos, sole ulcers and udder diseases. The aim of this report is to critically review, in accordance with the PRISMA guidelines, the available literature reporting clinical application in the bovine practice of PRP. Three bibliographic databases PubMed, Web of Science and Scopus were used for a broad search of "platelet concentrates" OR "PRP" OR "platelet-rich plasma" OR "PRF" OR "platelet-rich fibrin" AND "cows" OR "cattle". From 1196 papers, only six met the inclusion criteria. Two papers described the use of PRP in mastitis, two papers in uterine dysfunction and two papers in ovarian dysfunction. PRP offered a low-cost, easily obtained therapeutic option and showed positive results for these patients. However, given the different pathologies and definitions involved, further studies are necessary to assess its full clinical potential.
血小板浓缩物（PCs）已在兽医和人类医学中广泛应用。PCs主要由超生理浓度的血小板组成，因此也包含储存在血小板α颗粒中的生长因子（GFs）。在PCs中，富血小板血浆（PRP）的特点是含有低密度纤维蛋白。近年来，关于PCs对牛的影响的研究激增；特别是，有证据表明PRP在治疗生殖问题、牛胚胎的体外生产、蹄部溃疡和乳房疾病方面有积极作用。本报告的目的是根据PRISMA指南，严格审查现有的关于PRP在牛实践中的临床应用的文献。使用三个文献数据库PubMed、Web of Science和Scopus广泛搜索“血小板浓缩物”或“PRP”或“富血小板血浆”或“PRF”或“富血小板纤维蛋白”以及“奶牛”或“牛”。从1196篇论文中，只有6篇符合纳入标准。两篇论文描述了PRP在乳腺炎中的应用，两篇论文描述了其在子宫功能障碍中的应用，两篇论文描述了其在卵巢功能障碍中的应用。PRP提供了一种低成本、易于获得的治疗选择，并且对这些患者显示出了积极的效果。然而，鉴于所涉及的不同病理情况和定义，有必要进行进一步的研究来评估其全部临床潜力。
