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喉结核中巨噬细胞的存在:一例报告

Resides in Macrophages in Laryngeal Tuberculosis: A Case Report.

作者信息

Achache Wafaa, Boualam Mahmoud A, Cassir Nadim, Mimari Clémence, Poitrenaud Delphine, Mezouar Soraya, Mège Jean Louis, Drancourt Michel, Lepidi Hubert

机构信息

MEPHI, Aix-Marseille University, IRD, 13005 Marseille, France.

IHU Méditerranée Infection, 13005 Marseille, France.

出版信息

Pathogens. 2023 Nov 30;12(12):1413. doi: 10.3390/pathogens12121413.

Abstract

Laryngeal tuberculosis is a rare form of extrapulmonary tuberculosis that questions the natural history of this infection. We report one such case in which a pathological examination of a laryngeal biopsy revealed granulomatous inflammation with caseous necrosis. Further investigations combining immunofluorescence detection of macrophages and in situ hybridization of indicated the presence of () in laryngeal granulomatous inflammatory lesions. This observation suggests that the natural history of laryngeal tuberculosis does not differ from that of other forms, guiding early diagnosis in patients with laryngeal lesions to ensure appropriate check-ups and treatment.

摘要

喉结核是肺外结核的一种罕见形式,这对这种感染的自然史提出了疑问。我们报告了这样一例病例,其中喉活检的病理检查显示为伴有干酪样坏死的肉芽肿性炎症。结合巨噬细胞免疫荧光检测和原位杂交的进一步研究表明,在喉肉芽肿性炎症病变中存在()。这一观察结果表明,喉结核的自然史与其他形式的结核并无不同,这有助于指导对喉部病变患者进行早期诊断,以确保进行适当的检查和治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e2f/10745871/6b94afbfbbf1/pathogens-12-01413-g001.jpg

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