López-Botella Andrea, Gómez-Torres María José, Sánchez Raquel, Todolí-Torró José-Luis, Velasco Irene, Acién Maribel
Service of Obstetrics and Gynecology, Unit of Human Reproduction, FISABIO-San Juan University Hospital, Carretera Alicante-Valencia s/n, 03550 Sant Joan d'Alacant, Alicante, Spain.
Biotechnology Department, Faculty of Sciences, University of Alicante, Carretera San Vicente del Raspeig s/n, 03690 San Vicente del Raspeig, Alicante, Spain.
Toxics. 2023 Dec 10;11(12):1009. doi: 10.3390/toxics11121009.
Potentially toxic elements (PTEs), found as environmental contaminants, have been related to endometriosis disease. In this context, the peritoneal fluid (PF) matrix has been poorly studied despite its importance. PF is the environment in which endometriotic lesions reside and communicate with surrounding tissues including tissues and nerve cells. In this work, our investigation group reports the special case of a peritoneal endometriosis patient presenting elevated lead, nickel, and bismuth levels in PF. This patient reported following a vegetarian diet and no toxic habits or occupational exposure. In conclusion, the elevated levels of PTEs found may result from a vegetarian diet or an unidentified environmental exposure source. This report provides new insights regarding the possible etiology of endometriosis disease and potential biomarkers for its diagnosis in early stages, although additional research is needed.
作为环境污染物被发现的潜在有毒元素（PTEs）与子宫内膜异位症有关。在这种情况下，尽管腹膜液（PF）基质很重要，但对其研究甚少。PF是子宫内膜异位病变所在并与周围组织（包括组织和神经细胞）相互作用的环境。在这项工作中，我们的研究小组报告了一例腹膜子宫内膜异位症患者的特殊病例，该患者的PF中铅、镍和铋水平升高。该患者称遵循素食饮食，无有毒习惯或职业暴露史。总之，所发现的PTEs水平升高可能是由于素食饮食或不明环境暴露源所致。本报告为子宫内膜异位症的可能病因及早期诊断的潜在生物标志物提供了新的见解，不过仍需进一步研究。
