一种智能手机集成的双发射荧光纳米探针，用于可视化和比率检测炭疽生物标志物。
A smartphone-intergrated dual-emission fluorescent nanoprobe for visual and ratiometric detection of anthrax biomarkers.
机构信息
College of New Materials and Chemical Engineering, Beijing Institute of Petrochemical Technology, Beijing 102617, China; Beijing Key Laboratory of Fuels Cleaning and Advanced Catalytic Emission Reduction Technology, Beijing 102617, China.
College of New Materials and Chemical Engineering, Beijing Institute of Petrochemical Technology, Beijing 102617, China; Beijing Key Laboratory of Fuels Cleaning and Advanced Catalytic Emission Reduction Technology, Beijing 102617, China.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2024 Mar 5;308:123785. doi: 10.1016/j.saa.2023.123785. Epub 2023 Dec 16.
A novel dual-emission fluorescent nanoprobe based on rare-earth nanosheets was fabricated to detect 2,6-pyridine dicarboxylic acid (DPA), which is the biomarker of Bacillus anthracis. 2-amino terephthalic acid (BDC-NH) and surfactant sodium dodecyl sulfate (SDS) were co-intercalated into layered europium hydroxide (LEuH) to prepare the organic/inorganic composite, which was delaminated to obtain the rare-earth nanosheets. The ratio detection of DPA is possible due to the antenna effect between DPA and Eu. The nanoprobe shows high accuracy and sensitivity due to the large specific surface area of the rare-earth nanosheets. The limit of detection (LOD) is 4.4 nM for DPA in the range of 0-20 μM. In addition, a more convenient and faster smartphone-based visual detection platform was established based on the obvious color change. This work offers an effective way for developing visual sensing platforms, which opens a new path for designing fluorescent probes with superior sensing capabilities.
基于稀土纳米片的新型双发射荧光纳米探针被制备用于检测炭疽芽孢杆菌生物标志物 2,6-吡啶二甲酸（DPA）。2-氨基对苯二甲酸（BDC-NH）和表面活性剂十二烷基硫酸钠（SDS）共同插层到层状氢氧化铕（LEuH）中制备有机/无机复合材料，将其剥离以获得稀土纳米片。由于 DPA 和 Eu 之间的天线效应，可以实现 DPA 的比率检测。由于稀土纳米片的大比表面积，该纳米探针具有很高的准确性和灵敏度。在 0-20 μM 的范围内，DPA 的检测限（LOD）为 4.4 nM。此外，还基于明显的颜色变化建立了更方便、更快的基于智能手机的可视化检测平台。这项工作为开发可视化传感平台提供了一种有效方法，为设计具有优越传感性能的荧光探针开辟了新途径。
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