Nishioka K, Kobayashi Y, Katayama I, Takijiri C
Arch Dermatol. 1987 Feb;123(2):205-8.
Numbers of mast cells were quantitated in the lesions of diffuse scleroderma and morphea. Mast cells increased and then decreased in number in the papillary dermis of diffuse scleroderma. No significant change of mast cell numbers was noted in the reticular dermis. Mast cells increased in the papillary dermis with fine collagen bundles (grade 2 skin of scleroderma) and decreased in the papillary dermis with homogeneous collagen bundles (grade 3 skin of scleroderma). The total number of cells increased in the papillary dermis of grade 1 and 2 skin of scleroderma and decreased in the grade 3 skin of scleroderma. In morphea a reduced number of mast cells was noted in grade 3 lesions. It is suggested that mast cells play an important role in fibrotic process of scleroderma skin.
对弥漫性硬皮病和硬斑病皮损中的肥大细胞进行了定量分析。在弥漫性硬皮病的乳头层真皮中，肥大细胞数量先增加后减少。网状真皮中肥大细胞数量无显著变化。在伴有细胶原束的乳头层真皮（硬皮病2级皮肤）中肥大细胞增加，而在伴有均质胶原束的乳头层真皮（硬皮病3级皮肤）中肥大细胞减少。硬皮病1级和2级皮肤的乳头层真皮中细胞总数增加，而硬皮病3级皮肤中细胞总数减少。在硬斑病中，3级皮损中肥大细胞数量减少。提示肥大细胞在硬皮病皮肤的纤维化过程中起重要作用。
