肥大细胞在伤口愈合中的作用。
The role of mast cells in wound healing.
机构信息
Department of Wound Healing, School of Medicine, Cardiff University, UK. fee
出版信息
Int Wound J. 2010 Feb;7(1):55-61. doi: 10.1111/j.1742-481X.2009.00651.x.
Abstract
Mast cells are predominantly found in the vicinity of connective tissue vessels of skin and mucosa. The main immunological functions of mast cells are in IgE-mediated reactions and in helminth infestations. Mast cells respond to tissue injury by releasing inflammatory mediators and have been implicated in diseases of excessive fibrosis of the dermis such as scleroderma. Current evidence suggests that mast cells exert its role during inflammation and cellular proliferation. Animal models have shown that by stabilising mast cells at the early stages of wound healing, wound contraction is reduced. Mast cells are an ideal candidate to play a pivotal role in wound healing due to its location, substances released and clinical associations.
摘要
肥大细胞主要存在于皮肤和黏膜结缔组织血管附近。肥大细胞的主要免疫学功能是在 IgE 介导的反应和寄生虫感染中。肥大细胞通过释放炎症介质对组织损伤作出反应，并与真皮过度纤维化疾病（如硬皮病）有关。目前的证据表明，肥大细胞在炎症和细胞增殖过程中发挥作用。动物模型表明，通过在伤口愈合的早期稳定肥大细胞，可以减少伤口收缩。由于肥大细胞的位置、释放的物质和临床关联，它是在伤口愈合中发挥关键作用的理想候选者。
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