Kato T, Takematsu H, Tomita Y, Takahashi M, Abe R
Arch Dermatol. 1987 Feb;123(2):216-20.
We found 13 mucosal melanomas (13%) among 103 cases of malignant melanoma at Tohoku University Hospital, Sendai, Japan, a high incidence. Five melanomas were found on the oral mucosa, another five on the genital mucosa, two within the nasal cavity, and one on the esophagus. Three of the melanomas on the oral mucosa occurred on the lip and the other two on the gingiva. A striking prevalence of melanomas was observed in women, the male-to-female ratio being 0.08. Histologic examination revealed that 58% of the melanomas were characterized by lentiginous, 23% by nodular, and 15% by superficial spreading proliferation. Most of the melanomas were Clark's level IV or V at the time of diagnosis. Except for three who have been under observation for a short time, all the patients have died. There appear to be some clinical and histologic similarities between mucosal melanoma and melanoma of the volar skin, but the difference in biological behavior warrants that the two be classified separately.
我们在日本仙台东北大学医院的103例恶性黑色素瘤病例中发现了13例黏膜黑色素瘤（13%），这一发病率很高。5例黑色素瘤发生在口腔黏膜，另外5例在生殖器黏膜，2例在鼻腔内，1例在食管。口腔黏膜上的3例黑色素瘤发生在唇部，另外2例在牙龈。黑色素瘤在女性中显著高发，男女比例为0.08。组织学检查显示，58%的黑色素瘤具有雀斑样特征，23%为结节状，15%为浅表扩散性增殖。大多数黑色素瘤在诊断时处于克拉克四级或五级。除了3例短期观察的患者外，所有患者均已死亡。黏膜黑色素瘤与掌侧皮肤黑色素瘤之间似乎存在一些临床和组织学上的相似之处，但生物学行为的差异使得两者应分开分类。
