Bedi Rohil, Ahmad Ali, Horbal Piotr, Mar Philip L
Department of Internal Medicine, Saint Louis University School of Medicine St Louis, Missouri, US.
Division of Cardiovascular Medicine, Department of Internal Medicine, Ohio State University Columbus, Ohio, US.
Arrhythm Electrophysiol Rev. 2023 Aug 25;12:e24. doi: 10.15420/aer.2022.44. eCollection 2023.
Radiation-associated cardiovascular disease, an increasingly recognised disease process, is a significant adverse effect of radiation therapy for common malignancies that involve the chest, and include lymphomas, lung, mediastinal and breast cancers. Two factors contribute to the increasing incidence of radiation-associated cardiovascular disease: advances in malignancy detection and the improved survival of cancer patients, by which many symptoms of radiation-associated cardiovascular disease, specifically radiation-associated arrhythmias, present years and/or decades following initial radiotherapy. We present a focused overview of the currently understood pathophysiology, prevalence and management strategies of radiation-associated arrhythmias, which include bradyarrhythmias, tachyarrhythmias and autonomic dysfunction.
辐射相关的心血管疾病是一种日益受到认可的疾病过程，是胸部常见恶性肿瘤放射治疗的一种重大不良反应，这些恶性肿瘤包括淋巴瘤、肺癌、纵隔癌和乳腺癌。两个因素导致辐射相关心血管疾病的发病率上升：恶性肿瘤检测技术的进步以及癌症患者生存率的提高，由此许多辐射相关心血管疾病的症状，特别是辐射相关心律失常，在初次放疗后的数年和/或数十年出现。我们重点概述了目前所了解的辐射相关心律失常的病理生理学、患病率和管理策略，其中包括缓慢性心律失常、快速性心律失常和自主神经功能障碍。
