Teague Elisma, Bezuidenhout Selente, Meyer Johanna C, Godman Brian, Engler Deirdré
Department of Clinical Pharmacy, School of Pharmacy, Sefako Makgatho Health Sciences University, Molotlegi Street, Ga-Rankuwa Zone 1, Ga-Rankuwa 0208, South Africa.
Department of Public Health Pharmacy and Management, School of Pharmacy, Sefako Makgatho Health Sciences University, Molotlegi Street, Ga-Rankuwa Zone 1, Ga-Rankuwa 0208, South Africa.
Antibiotics (Basel). 2023 Dec 16;12(12):1742. doi: 10.3390/antibiotics12121742.
Antimicrobial resistance (AMR) is being increasingly seen as the next pandemic due to high morbidity and mortality rates, with Sub-Saharan Africa currently having the highest mortality rates driven by high rates of inappropriate prescribing in ambulatory care. In South Africa, nurses typically provide a range of services, including prescribing, in public ambulatory care clinics. However, little is currently known about the perception of final-year nursing students regarding antibiotic use, AMR, and antimicrobial stewardship (AMS). Consequently, we sought to address this important evidence gap. A quantitative descriptive study using a self-administered online questionnaire via Google Forms was undertaken among six universities in South Africa offering a Baccalaureus of Nursing. Knowledge on the classes of antibiotics, organisms covered, and mechanism of action was lacking. The sample size to achieve a confidence interval of 95% with a 5% error margin was 174, increased to 200 to compensate for possible attrition. Only 15.3% of nurses knew that ceftazidime is not a fourth-generation cephalosporin, and only 16.1% knew that clavulanic acid does not decrease inflammation at the site of infection. In addition, only 58.9% and 67.7% agreed that the prescribing of broad-spectrum antibiotics and poor infection control, respectively, increase AMR. AMS was also not a well-known concept among final-year nurses. The lack of knowledge regarding antibiotics, AMR, and AMS among final-year nurses could have important repercussions in practice once these nurses are qualified. Consequently, this information gap needs to be urgently addressed going forward with updated curricula and post-qualification educational activities to reduce AMR in South Africa.
由于高发病率和死亡率，抗菌药物耐药性（AMR）日益被视为下一场大流行，撒哈拉以南非洲目前因门诊护理中不适当处方率高而死亡率最高。在南非，护士通常在公共门诊护理诊所提供一系列服务，包括开处方。然而，目前对于护理学本科最后一年学生对抗生素使用、AMR和抗菌药物管理（AMS）的认知了解甚少。因此，我们试图填补这一重要的证据空白。我们在南非提供护理学学士学位的六所大学中，通过谷歌表单进行了一项使用自填式在线问卷的定量描述性研究。学生们对抗生素类别、所涵盖的微生物以及作用机制方面的知识较为欠缺。要在误差幅度为5%的情况下实现95%的置信区间，样本量应为174，为补偿可能的损耗将其增加到200。只有15.3%的护士知道头孢他啶不是第四代头孢菌素，只有16.1%的护士知道克拉维酸不会减轻感染部位的炎症。此外，分别只有58.9%和67.7%的人认为开具广谱抗生素和感染控制不佳会增加AMR。AMS在护理学本科最后一年的学生中也不是一个广为人知的概念。护理学本科最后一年学生在抗生素、AMR和AMS方面缺乏知识，一旦这些护士获得资格，在实际工作中可能会产生重要影响。因此，需要通过更新课程和资格后教育活动来紧急填补这一信息空白，以降低南非的AMR。
