Hanna Colin, Yao Rutao, Sajjad Munawwar, Gold Mark, Blum Kenneth, Thanos Panayotis K
Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacob School of Medicine and Biosciences, State University of New York at Buffalo, Buffalo, NY 14203, USA.
Department of Nuclear Medicine, State University of New York at Buffalo, Buffalo, NY 14203, USA.
Brain Sci. 2023 Dec 11;13(12):1705. doi: 10.3390/brainsci13121705.
It is well known that exercise promotes health and wellness, both mentally and physiologically. It has been shown to play a protective role in many diseases, including cardiovascular, neurological, and psychiatric diseases. The present study examined the effects of aerobic exercise on brain glucose metabolic activity in response to chronic cocaine exposure in female Lewis rats. Rats were divided into exercise and sedentary groups. Exercised rats underwent treadmill running for six weeks and were compared to the sedentary rats. Using positron emission tomography (PET) and [18F]-Fluorodeoxyglucose (FDG), metabolic changes in distinct brain regions were observed when comparing cocaine-exposed exercised rats to cocaine-exposed sedentary rats. This included activation of the secondary visual cortex and inhibition in the cerebellum, stria terminalis, thalamus, caudate putamen, and primary somatosensory cortex. The functional network of this brain circuit is involved in sensory processing, fear and stress responses, reward/addiction, and movement. These results show that chronic exercise can alter the brain metabolic response to cocaine treatment in regions associated with emotion, behavior, and the brain reward cascade. This supports previous findings of the potential for aerobic exercise to alter the brain's response to drugs of abuse, providing targets for future investigation. These results can provide insights into the fields of exercise neuroscience, psychiatry, and addiction research.
众所周知，运动能促进身心健康，无论是在心理上还是生理上。研究表明，运动在许多疾病中都起到保护作用，包括心血管疾病、神经疾病和精神疾病。本研究考察了有氧运动对雌性Lewis大鼠慢性可卡因暴露后脑葡萄糖代谢活性的影响。大鼠被分为运动组和久坐组。运动组大鼠进行六周的跑步机跑步，并与久坐组大鼠进行比较。使用正电子发射断层扫描（PET）和[18F] -氟脱氧葡萄糖（FDG），比较可卡因暴露的运动大鼠和可卡因暴露的久坐大鼠时，观察到不同脑区的代谢变化。这包括次级视觉皮层的激活以及小脑、终纹床核、丘脑、尾状壳核和初级体感皮层的抑制。该脑回路的功能网络涉及感觉处理、恐惧和应激反应、奖赏/成瘾以及运动。这些结果表明，长期运动可以改变与情绪、行为和脑奖赏级联相关区域对可卡因治疗的脑代谢反应。这支持了先前关于有氧运动可能改变大脑对滥用药物反应的研究结果，为未来的研究提供了靶点。这些结果可以为运动神经科学、精神病学和成瘾研究领域提供见解。
