Sawicka-Gutaj Nadia, Derwich-Rudowicz Aleksandra, Biczysko Aleksandra, Turchyn Solomiya, Ziółkowska Paulina, Ziemnicka Katarzyna, Gut Paweł, Nijakowski Kacper, Ruchała Marek
Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
Department of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, 60-812 Poznan, Poland.
Biomedicines. 2023 Dec 11;11(12):3278. doi: 10.3390/biomedicines11123278.
Acromegaly is a chronic disease caused by the hypersecretion of growth hormone (GH), leading to changes in the growth of visceral tissues and glucose impairment. Serum biomarkers that correlate with disease status are still unclear. This study aims to assess the potential of phosphorus and calcium as biomarkers in the clinical evaluation of patients with acromegaly and clarify their relationship with SAGIT and other common biomarkers. We retrospectively analyzed data from 306 medical records of patients with acromegaly hospitalized between 2015 and 2020. Factors such as patient biometrics, duration of disease, SAGIT score, tumor size, GH, insulin-like growth factor 1 (IGF-1), calcium, phosphorus, parathormone, and vitamin D were analyzed concerning current disease status (naïve, non-remission, remission). The results showed that serum phosphorus significantly correlated with IGF-1 and SAGIT scores for patients with active acromegaly. Specifically, the best predictor for the remission of acromegaly was a phosphorus level < 3.98 mg/dL and serum calcium levels < 9.88 mg/dL. Based on logistic regression, the higher the serum phosphorus level, the lower the odds of achieving remission (an increase in one unit leads to a decrease in the chance of about 80%). In conclusion, phosphorus and calcium can be effective biochemical markers for predicting disease status in acromegaly.
肢端肥大症是一种由生长激素（GH）分泌过多引起的慢性疾病，会导致内脏组织生长改变和葡萄糖代谢受损。与疾病状态相关的血清生物标志物仍不明确。本研究旨在评估磷和钙作为肢端肥大症患者临床评估生物标志物的潜力，并阐明它们与SAGIT及其他常见生物标志物的关系。我们回顾性分析了2015年至2020年期间住院的306例肢端肥大症患者的病历数据。分析了患者生物特征、病程、SAGIT评分、肿瘤大小、GH、胰岛素样生长因子1（IGF-1）、钙、磷、甲状旁腺激素和维生素D等因素与当前疾病状态（初治、未缓解、缓解）的关系。结果显示，对于活动期肢端肥大症患者，血清磷与IGF-1及SAGIT评分显著相关。具体而言，肢端肥大症缓解的最佳预测指标是磷水平<3.98mg/dL和血清钙水平<9.88mg/dL。基于逻辑回归分析，血清磷水平越高，缓解的几率越低（每增加一个单位，缓解机会约降低80%）。总之，磷和钙可作为预测肢端肥大症疾病状态的有效生化标志物。
