高流量气管给氧用于肺移植受者气管造口管拔除

High-Flow Tracheal Oxygen for Tracheostomy Tube Removal in Lung Transplant Recipients.

作者信息

Lionello Federico, Guarnieri Gabriella, Arcaro Giovanna, Bertagna De Marchi Leonardo, Molena Beatrice, Contessa Cristina, Boscolo Annalisa, Rea Federico, Navalesi Paolo, Vianello Andrea

机构信息

Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35131 Padova, Italy.

Department of Directional Hospital Management, University of Padova, 35131 Padova, Italy.

出版信息

J Clin Med. 2023 Dec 8;12(24):7566. doi: 10.3390/jcm12247566.

DOI:10.3390/jcm12247566

PMID:38137635

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10743481/

Abstract

(1) Background: Because of a complicated intraoperative course and/or poor recovery of graft function, approximately 15% of lung transplant (LT) recipients require prolonged mechanical ventilation (PMV) and receive a tracheostomy. This prospective study aimed to assess the effect of High-Flow Tracheal Oxygen (HFTO) on tracheostomy tube removal in LT recipients receiving PMV postoperatively. (2) Methods: The clinical course of 14 LT recipients receiving HFTO was prospectively evaluated and compared to that of 13 comparable controls receiving conventional oxygen therapy (COT) via tracheostomy. The study's primary endpoint was the number of patients whose tracheostomy tube was removed at discharge from an Intermediate Respiratory Care Unit (IRCU). (3) Results: Setting up HFTO proved easy, and it was well tolerated by all the patients. The number of patients whose tracheostomy tube was removed was significantly higher in the HFOT group compared to the COT group [13/14 vs. 6/13 ( 0.0128)]. (4) Conclusions: HFTO is an effective, safe therapy that facilitates tracheostomy tube removal in LT recipients after weaning from PMV.

摘要

(1) 背景：由于术中过程复杂和/或移植肺功能恢复不佳，约15%的肺移植（LT）受者需要长时间机械通气（PMV）并接受气管切开术。本前瞻性研究旨在评估高流量气管给氧（HFTO）对术后接受PMV的LT受者气管切开管拔除的影响。(2) 方法：前瞻性评估14例接受HFTO的LT受者的临床过程，并与13例通过气管切开接受传统氧疗（COT）的对照者进行比较。研究的主要终点是在中级呼吸护理病房（IRCU）出院时拔除气管切开管的患者数量。(3) 结果：事实证明，设置HFTO很容易，所有患者对其耐受性良好。与COT组相比，HFOT组拔除气管切开管的患者数量显著更高[13/14对6/13（P=0.0128）]。(4) 结论：HFTO是一种有效、安全的治疗方法，有助于PMV撤机后的LT受者拔除气管切开管。