Coppola Andrea, Grasso Dario, Fontana Federico, Piacentino Filippo, Minici Roberto, Laganà Domenico, Ierardi Anna Maria, Carrafiello Gianpaolo, D'Angelo Fabio, Carcano Giulio, Venturini Massimo
Diagnostic and Interventional Radiology Unit, Circolo Hospital, ASST Sette Laghi, 21100 Varese, Italy.
Department of Medicine and Technological Innovation, Insubria University, 21100 Varese, Italy.
J Clin Med. 2023 Dec 14;12(24):7677. doi: 10.3390/jcm12247677.
Pancreatic ductal adenocarcinoma (PDAC) is a cancer with one of the highest mortality rates in the world. Several studies have been conductedusing preclinical experiments in mice to find new therapeutic strategies. Experimental ultrasound, in expert hands, is a safe, multifaceted, and relatively not-expensive device that helps researchers in several ways. In this systematic review, we propose a summary of the applications of ultrasonography in a preclinical mouse model of PDAC. Eighty-eight studies met our inclusion criteria. The included studies could be divided into seven main topics: ultrasound in pancreatic cancer diagnosis and progression (n: 21); dynamic contrast-enhanced ultrasound (DCE-US) (n: 5); microbubble ultra-sound-mediated drug delivery; focused ultrasound (n: 23); sonodynamic therapy (SDT) (n: 7); harmonic motion elastography (HME) and shear wave elastography (SWE) (n: 6); ultrasound-guided procedures (n: 9). In six cases, the articles fit into two or more sections. In conclusion, ultrasound can be a really useful, eclectic, and ductile tool in different diagnostic areas, not only regarding diagnosis but also in therapy, pharmacological and interventional treatment, and follow-up. All these multiple possibilities of use certainly represent a good starting point for the effective and wide use of murine ultrasonography in the study and comprehensive evaluation of pancreatic cancer.
胰腺导管腺癌（PDAC）是一种死亡率位居世界前列的癌症。已有多项研究利用小鼠的临床前实验来探寻新的治疗策略。在专业人员手中，实验性超声是一种安全、多功能且成本相对较低的设备，能在多个方面助力研究人员。在本系统综述中，我们对超声检查在PDAC临床前小鼠模型中的应用进行了总结。88项研究符合我们的纳入标准。纳入的研究可分为七个主要主题：超声在胰腺癌诊断及病情进展中的应用（数量：21）；动态对比增强超声（DCE-US）（数量：5）；微泡超声介导的药物递送；聚焦超声（数量：23）；声动力疗法（SDT）（数量：7）；谐波运动弹性成像（HME）和剪切波弹性成像（SWE）（数量：6）；超声引导下的操作（数量：9）。有6篇文章涉及两个或更多类别。总之，超声在不同诊断领域可以是一种非常有用、兼收并蓄且灵活多变的工具，不仅在诊断方面，在治疗、药物和介入治疗以及随访中也是如此。所有这些多样的应用可能性无疑是在胰腺癌研究和综合评估中有效且广泛应用小鼠超声检查的良好起点。
