头孢呋辛在白化大鼠骨骼中的浓度：股骨、肱骨和下颌骨的比较研究。

Concentration of cefuroxime in the bones of albino white rats: a comparative study of femur, humerus, and mandible.

作者信息

Papadopulos J, Patrikiou A, Mandalenakis C, Capri C

出版信息

Arch Orthop Trauma Surg (1978). 1986;105(6):373-4. doi: 10.1007/BF00449946.

Abstract

The levels of cefuroxime in rat bones with a different morphology, function, blood supply, and proportion between lamellar and cancellous bone were studied, after a 24-h administration of 750mg/kg X 3. The concentrations in the right and left femora, humeri, and mandibles of the same animal were measured 2 h after the last administration. The result indicate statistically significant differences between femur and humerus (P less than 0.001), femur and mandible (P less than 0.05), and humerus and mandible (P less than 0.05).

摘要

在以750mg/kg的剂量给药3次、时长24小时后，研究了头孢呋辛在大鼠不同形态、功能、血液供应以及骨密质与骨松质比例的骨骼中的含量。在最后一次给药2小时后，测量同一动物左右股骨、肱骨和下颌骨中的浓度。结果表明，股骨与肱骨之间（P<0.001）、股骨与下颌骨之间（P<0.05）以及肱骨与下颌骨之间（P<0.05）存在统计学上的显著差异。