Sakata E, Kitago Y, Murata Y, Teramoto K
Auris Nasus Larynx. 1986;13(2):79-89. doi: 10.1016/s0385-8146(86)80002-5.
Before considering the surgical treatment of patients with Ménière disease who would resist to various conservative therapies, including oral drug therapy, the author experimented the inner ear anesthetic therapy or the middle ear infusion therapy with a steroid solution, and each therapeutic result was compared. The results were as follows: 1) The effectiveness of the inner ear anesthetic therapy for vertigo was noted in 42 ears out of the total 47, while the effectiveness of the middle ear steroid infusion therapy for vertigo was found in all treated 21 ears. 2) Although both therapies proved non-effective for hearing disturbance, excluding special cases, the former therapy was found effective for it in 26 ears among 42. 3) For other concomitant symptoms such as the full sensation of ear obturation, head heaviness, and stiff shoulders, both therapies were considerably effective. It was concluded from these results that the first choice of therapy for patients with Ménière disease who should resist to all conservative therapies should be the middle ear steroid infusion therapy at the out-patient clinic, and the second choice would be the inner ear anesthetic therapy, and that both therapies were worth while experimenting before considering surgical treatment.
在考虑对各种保守治疗（包括口服药物治疗）均无效的梅尼埃病患者进行手术治疗之前，作者对其进行了内耳麻醉疗法或中耳类固醇溶液灌注疗法，并比较了每种治疗方法的效果。结果如下：1）在内耳麻醉疗法中，47只耳朵中有42只眩晕症状得到缓解，而在中耳类固醇灌注疗法中，所有21只接受治疗的耳朵眩晕症状均得到缓解。2）尽管两种疗法对听力障碍均无效，但排除特殊情况后，内耳麻醉疗法在42只耳朵中有26只对听力障碍有效。3）对于其他伴随症状，如耳闷胀感、头部沉重感和肩部僵硬等，两种疗法均有显著疗效。从这些结果可以得出结论，对于所有保守治疗均无效的梅尼埃病患者，首选的治疗方法应该是门诊中耳类固醇灌注疗法，其次是内耳麻醉疗法，并且在考虑手术治疗之前，这两种疗法都值得尝试。
