PIMIT-Processus Infectieux en Milieu Insulaire Tropical, Université de La Réunion, INSERM UMR 1187, CNRS 9192, IRD 249, Plateforme CYROI, 97490 Sainte-Clotilde, France.
INSERM, UMR 1188 Diabète Athérothrombose Réunion Océan Indien (DéTROI), Université de La Réunion, Campus Santé de Terre Sainte, 97410 Saint-Pierre, France.
Viruses. 2023 Dec 9;15(12):2399. doi: 10.3390/v15122399.
In recent years, the emergence of the concept of immunometabolism has shed light on the pivotal role that cellular metabolism plays in both the activation of immune cells and the development of immune programs. The antiviral response, a widely distributed defense mechanism used by infected cells, serves to not only control infections but also to attenuate their deleterious effects. The exploration of the role of metabolism in orchestrating the antiviral response represents a burgeoning area of research, especially considering the escalating incidence of viral outbreaks coupled with the increasing prevalence of metabolic diseases. Here, we present a review of current knowledge regarding immunometabolism and the antiviral response during viral infections. Initially, we delve into the concept of immunometabolism by examining its application in the field of cancer-a domain that has long spearheaded inquiries into this fascinating intersection of disciplines. Subsequently, we explore examples of immune cells whose activation is intricately regulated by metabolic processes. Progressing with a systematic and cellular approach, our aim is to unravel the potential role of metabolism in antiviral defense, placing significant emphasis on the innate and canonical interferon response.
近年来，免疫代谢的概念的出现揭示了细胞代谢在免疫细胞的激活和免疫程序的发展中所起的关键作用。抗病毒反应是一种广泛分布的防御机制，被感染的细胞用来不仅控制感染，而且减轻其有害影响。代谢在协调抗病毒反应中的作用的探索是一个新兴的研究领域，特别是考虑到病毒爆发的发生率不断上升，加上代谢疾病的患病率不断增加。在这里，我们回顾了目前关于病毒感染期间免疫代谢和抗病毒反应的知识。首先，我们通过研究癌症领域中免疫代谢的应用来深入了解这个概念，癌症领域长期以来一直引领着对这一迷人的学科交叉领域的探索。随后，我们探讨了一些免疫细胞，其激活受到代谢过程的精细调节。我们采用系统和细胞的方法进行研究，旨在揭示代谢在抗病毒防御中的潜在作用，特别强调先天和经典干扰素反应。
