Medical College of Georgia at Augusta University, Augusta, GA, USA.
Department of Neurology, University of Utah, Salt Lake City, UT, USA.
Amyotroph Lateral Scler Frontotemporal Degener. 2024 May;25(3-4):420-423. doi: 10.1080/21678421.2023.2296557. Epub 2023 Dec 23.
Lion's Mane ( has historically been used as traditional medicine in Asia and Europe for its potential benefits in fighting infection and cancer. It has gained interest in the neurodegenerative disease field because of its mechanisms of action; these include anti-inflammation, neuroprotection, and promoting neurite growth demonstrated in various cell and animal models. A very small, double-blind, placebo-controlled trial in patients with mild cognitive impairment showed a temporary improvement in cognitive function; this finding has yet to be replicated. However, there have been no studies in ALS cell or animal models or in humans with ALS. Lion's Mane appears safe and inexpensive when consumed in powder or capsule, but one anaphylactic case was reported after a patient consumed fresh Lion's Mane mushroom. Currently, we do not have enough information to support the use of Lion's Mane for treating ALS. We support further research in ALS disease models and clinical trials to study its efficacy.
猴头菇（学名：Hericium erinaceus），在亚洲和欧洲的传统医学中，因其具有抗感染和抗癌的潜在功效而被广泛使用。由于其作用机制包括抗炎、神经保护和促进神经突生长，它在神经退行性疾病领域引起了人们的兴趣。在轻度认知障碍患者中进行的一项非常小的、双盲、安慰剂对照试验表明，认知功能有暂时的改善；但这一发现尚未得到复制。然而，在肌萎缩侧索硬化症的细胞或动物模型中，或在肌萎缩侧索硬化症患者中，尚未有研究进行。猴头菇以粉末或胶囊形式食用时安全且价格低廉，但有一例过敏报告是在患者食用新鲜猴头菇后发生的。目前，我们没有足够的信息来支持使用猴头菇治疗肌萎缩侧索硬化症。我们支持在肌萎缩侧索硬化症疾病模型和临床试验中进行进一步的研究，以评估其疗效。
