Hedges J R, Otten E J, Schroeder T J, Tasset J J
Am J Emerg Med. 1987 Jan;5(1):48-51. doi: 10.1016/0735-6757(87)90289-0.
Plasma amitriptyline concentrations were measured serially in nine overdose patients and correlated with the timing and amount of each patient's initial activated charcoal therapy. A direct correlation was found between the time to initial charcoal therapy (Tc) and the plasma concentration half-life of amitriptyline (T 1/2) calculated for the first seven to 18 hours of hospitalization; T 1/2 = 2.68 + 0.047 Tc (r = 0.78, P less than 0.05). An inverse trend of T 1/2 with the initial amount of charcoal administered was also noted. Nortriptyline, the major metabolite of amitriptyline, decreased in two of three patients who received greater than or equal to 50 gm of activated charcoal within 60 minutes of presentation. These findings support previous in vitro and human volunteer studies advocating the rapid administration of activated charcoal in acute tricyclic antidepressant overdoses.
对9名服药过量患者连续测量血浆阿米替林浓度，并将其与每位患者首次活性炭治疗的时间和剂量相关联。研究发现，首次活性炭治疗时间（Tc）与住院前7至18小时计算的阿米替林血浆浓度半衰期（T 1/2）之间存在直接相关性；T 1/2 = 2.68 + 0.047 Tc（r = 0.78，P < 0.05）。还注意到T 1/2与首次给予的活性炭剂量呈相反趋势。在就诊后60分钟内接受≥50克活性炭治疗的3名患者中，有2名患者的阿米替林主要代谢产物去甲替林减少。这些发现支持了先前的体外研究和人体志愿者研究，这些研究主张在急性三环类抗抑郁药过量时快速给予活性炭。
