Lipscomb D J, Widdop B
Arch Toxicol. 1975 Sep 5;34(1):37-46. doi: 10.1007/BF00353337.
Pigs were given large oral doses of paracetamol, amylobarbitone and amitriptyline. The effect of administering activated charcoal at varying intervals after dosing on the blood drug-level profiles of paracetamol and amylobarbitone was assessed by comparison with the profiles obtained when charcoal therapy was withheld. An appreciable effect on paracetamol absorption was demonstrated when charcoal was given up to 1 h after dosing. The amylobarbitone-dosed pigs exhibited delayed gastro-intestinal absorption of drug and this was substantially reduced by activated charcoal given 4 hrs after dosing. The pigs metabolised amitriptyline at too high a rate for meaningful studies to be undertaken with this drug.
给猪口服大剂量的对乙酰氨基酚、戊巴比妥和阿米替林。通过与未进行活性炭治疗时获得的血药浓度曲线进行比较，评估给药后不同时间间隔给予活性炭对乙酰氨基酚和戊巴比妥血药浓度曲线的影响。给药后1小时内给予活性炭对乙酰氨基酚的吸收有明显影响。给予戊巴比妥的猪表现出药物胃肠道吸收延迟，给药后4小时给予活性炭可使其显著降低。猪对阿米替林的代谢速度太快，无法用该药物进行有意义的研究。
