Yamaguchi Y
No To Shinkei. 1986 Nov;38(11):1027-34.
There have been many reports that had discussed the effectiveness of shunt surgery in dementia patients. But it is not always reliable to predict such effectiveness before the operation. We used auditory evoked brain stem responses (ABR) to investigate the degree of brain damage in normal pressure hydrocephalus (NPH) and predict the effectiveness of shunt surgery. Fifteen patients with subarachnoid hemorrhage were divided into three groups, 5 cases without any symptoms of NPH, 6 cases with one of three symptoms of NPH and 4 cases with full blown symptoms of NPH which improved after shunt surgery, it is NPH. Eleven cases of aged patients were classified into two groups, Elderly normal (6 cases) and Elderly dementia (5 cases) groups, Younger normal group was composed of 8 healthy persons. Interpeak latencies (IPL's) on ABR was used as indexes of evaluating brain stem function, I-V IPL was used as central transmission time (CTT). CTT of Younger normal group and Elderly normal group were not different. It showed that CTT was a reliable parameter of ABR independently of age. There was significant prolongation of CTT in the patients of NPH and Elderly dementia group in comparison with other groups, However between them significant differences were not present. We concluded that there was some degree of brain stem dysfunction in the patients of NPH as well as dementia patients suggesting one aspect of the pathogenesis of NPH. But we could not distinguish the patients of NPH from other dementia patients by the analysis of ABR.
已有许多报告讨论了分流手术对痴呆患者的有效性。但在手术前预测这种有效性并不总是可靠的。我们使用听觉诱发电位脑干反应(ABR)来研究正常压力脑积水(NPH)患者的脑损伤程度,并预测分流手术的有效性。15例蛛网膜下腔出血患者被分为三组,5例无任何NPH症状,6例有NPH三种症状之一,4例有典型NPH症状且分流手术后症状改善,这就是NPH。11例老年患者被分为两组,老年正常组(6例)和老年痴呆组(5例),年轻正常组由8名健康人组成。ABR的峰间潜伏期(IPL)用作评估脑干功能的指标,I-V IPL用作中枢传导时间(CTT)。年轻正常组和老年正常组的CTT无差异。这表明CTT是ABR的一个可靠参数,与年龄无关。与其他组相比,NPH患者和老年痴呆组患者的CTT明显延长,然而它们之间没有显著差异。我们得出结论,NPH患者以及痴呆患者存在一定程度的脑干功能障碍,这提示了NPH发病机制的一个方面。但通过ABR分析,我们无法将NPH患者与其他痴呆患者区分开来。