口服二氮嗪治疗六年期间原发性肺动脉高压的可逆性
Reversibility of primary pulmonary hypertension during six years of treatment with oral diazoxide.
作者信息
Chan N S, McLay J, Kenmure A C
出版信息
Br Heart J. 1987 Feb;57(2):207-9. doi: 10.1136/hrt.57.2.207.
Abstract
A 32 year old woman presented with a syncopal attack and dyspnoea on exertion. A diagnosis of primary pulmonary hypertension was confirmed by clinical examination, cardiac catheterisation, and pulmonary angiography. Her symptoms resolved completely with oral diazoxide and the pulmonary arterial pressure was reduced to normal levels over a period of six years. When diazoxide was discontinued on two separate occasions pulmonary hypertension recurred. This demonstrated the continued presence of the underlying stimulus for vasoconstriction.
摘要
一名32岁女性出现晕厥发作和劳力性呼吸困难。通过临床检查、心导管检查和肺血管造影确诊为原发性肺动脉高压。口服二氮嗪后她的症状完全缓解，肺动脉压在六年内降至正常水平。当二氮嗪在两个不同时间停用后，肺动脉高压复发。这表明血管收缩的潜在刺激因素持续存在。
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