二氮嗪治疗原发性肺动脉高压
Diazoxide in treatment of primary pulmonary hypertension.
作者信息
Wang S W, Pohl J E, Rowlands D J, Wade E G
出版信息
Br Heart J. 1978 May;40(5):572-4. doi: 10.1136/hrt.40.5.572.
Abstract
Three patients with primary pulmonary hypertension and one man with suspected thromboembolic pulmonary hypertension were given up to 300 mg diazoxide by injection into the pulmonary artery. The three patients with primary pulmonary hypertension responded with a fall in total pulmonary resistance and a rise in cardiac output. The patient with suspected thromboembolic pulmonary hypertension did not respond. Haemodynamic and clinical improvement was maintained by oral diazoxide in two of the responders, and in one the prognosis appeared to be greatly improved.
摘要
三名原发性肺动脉高压患者和一名疑似血栓栓塞性肺动脉高压的男性患者通过向肺动脉注射给予高达300毫克的二氮嗪。三名原发性肺动脉高压患者的总肺阻力下降，心输出量增加。疑似血栓栓塞性肺动脉高压的患者没有反应。两名有反应的患者通过口服二氮嗪维持了血流动力学和临床改善，其中一名患者的预后似乎有很大改善。
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