霍奇金病：约克郡的病例对照流行病学研究。
Hodgkin's disease: case control epidemiological study in Yorkshire.
作者信息
Bernard S M, Cartwright R A, Darwin C M, Richards I D, Roberts B, O'Brien C, Bird C C
出版信息
Br J Cancer. 1987 Jan;55(1):85-90. doi: 10.1038/bjc.1987.18.
Abstract
This is the first report of a case-control epidemiological study on lymphomas and leukaemias occurring in Yorkshire during 1979-84. This paper deals with the results of the Hodgkin's disease analysis comprising 248 cases and 489 controls. The results indicate support for previous work with respect to small family size and past history of infectious mononucleosis. Positive observations made in a previous pilot study are also confirmed and extended with respect to associations with certain chronic skin lesions, dental anaesthesia and familial factors. Negative associations are described with respect to X-ray exposures and cigarette smoking. It is proposed that these results fit into a general hypothesis that these conditions are the result of interaction between infectious agents and altered immunity in those persons genetically predisposed.
摘要
这是关于1979 - 1984年间在约克郡发生的淋巴瘤和白血病的病例对照流行病学研究的首次报告。本文论述了霍奇金病分析的结果，该分析包含248例病例和489名对照。结果表明支持先前关于小家庭规模和传染性单核细胞增多症既往史的研究。先前一项初步研究中的阳性观察结果在与某些慢性皮肤病变、牙科麻醉和家族因素的关联方面也得到了证实和扩展。还描述了与X射线照射和吸烟的负相关。有人提出，这些结果符合一个总体假设，即这些病症是感染因子与那些具有遗传易感性的人免疫改变之间相互作用的结果。
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本文引用的文献
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Malignant lymphoma in first-degree blood relatives.一级血亲中的恶性淋巴瘤。
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Yorkshire Regional Lymphoma Histopathology panel: analysis of five years' experience.约克郡地区淋巴瘤组织病理学小组：五年经验分析
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Atopic dermatitis and Hodgkin's disease.特应性皮炎与霍奇金病。
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Characteristics in youth indicative of adult-onset Hodgkin's disease.提示成人起病型霍奇金淋巴瘤的青年期特征。
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Familial Hodgkin's disease.家族性霍奇金病。
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