Ferrant A, Leners N, Michaux J L, Verwilghen R L, Sokal G
Br J Haematol. 1987 Jan;65(1):31-4. doi: 10.1111/j.1365-2141.1987.tb06131.x.
The mean intrasplenic red cell transit time (STT) and the slow mixing splenic red cell volume (SSV) have been measured in patients with hereditary spherocytosis (HS), autoimmune haemolytic anaemia (AIHA) and lymphoproliferative disease (LD). There was an inverse relationship between the mean red cell life span (MRCLS) and the STT in HS (r = -0.96, P less than 0.001) and in AIHA (r = -0.90, P less than 0.001). No such relationship existed in LD. The size of the spleen and the SSV were not related to the severity of haemolysis. Our data offer strong evidence for the conditioning effect of the spleen on HS- and AIHA red cells and suggest that the STT is an index of the adverse effect of the spleen on red cells in patients with HS or AIHA.
已对遗传性球形红细胞增多症（HS）、自身免疫性溶血性贫血（AIHA）和淋巴增殖性疾病（LD）患者的脾内平均红细胞通过时间（STT）和缓慢混合脾红细胞体积（SSV）进行了测量。在HS患者中，平均红细胞寿命（MRCLS）与STT呈负相关（r = -0.96，P < 0.001），在AIHA患者中也是如此（r = -0.90，P < 0.001）。在LD患者中不存在这种关系。脾脏大小和SSV与溶血严重程度无关。我们的数据为脾脏对HS和AIHA红细胞的调节作用提供了有力证据，并表明STT是脾脏对HS或AIHA患者红细胞产生不良影响的一个指标。
