Lavrent'ev V V, Chasovnikova L V, Kurek A K, Aleshkin V A
Biofizika. 1987 Jan-Feb;32(1):37-41.
Molecules of normal mouse IgG are oriented horizontally in monolayers at air-water interface unlike the molecules of mouse IgG1 kappa secreted by MOPC-21 myeloma which have vertical orientation. Sodium desoxycholate processing of both preparations at concentrations below the critical micelle concentration resulted in abnormal IgG1 kappa preservation and normal IgG acquisition of vertical orientation in monolayers. When sodium desoxycholate was used for IgG modification at concentration higher than the critical micelle concentration both normal and abnormal IgG had horizontal orientation in monolayers.
与MOPC - 21骨髓瘤分泌的呈垂直取向的小鼠IgG1 κ分子不同，正常小鼠IgG分子在空气 - 水界面的单分子层中呈水平取向。在低于临界胶束浓度的浓度下对两种制剂进行脱氧胆酸钠处理，导致单分子层中异常IgG1 κ得以保留，正常IgG获得垂直取向。当以高于临界胶束浓度的浓度使用脱氧胆酸钠对IgG进行修饰时，正常和异常IgG在单分子层中均呈水平取向。
