Division of Surgical Research, Department of Surgery, Rhode Island Hospital, Brown University School of Medicine, 593 Eddy Street, Providence, Rhode Island, 02903, USA.
Division of Surgical Research, Department of Surgery, Rhode Island Hospital, Brown University School of Medicine, Room 205 Middle House, Providence, Rhode Island, 02903, USA.
Inflamm Res. 2024 Jan;73(1):1-4. doi: 10.1007/s00011-023-01795-z. Epub 2023 Dec 26.
iNKT-cells are innate regulatory lymphocytes capable of directing immune and inflammatory responses to sepsis. Repeat stimulation of iNKT-cells leads to the induction of anergy with the emergence of a hyporesponsive CD3 iNKT-cell subpopulation.
iNKT-cells were isolated from critical ill surgical patients with sepsis and phenotyped for CD3 expression. This was correlated with degree of severity of illness, as denoted by APACHE-II score.
Comparing healthy volunteers to critically ill septic patients, it was noted that increasing severity of sepsis was associated with increasing frequency of circulating CD3-iNKT-cell populations.
The emergence of CD3 -iNKT-cells may serve as a clinically translatable marker of degree of sepsis-induced immune dysfunction.
iNKT 细胞是先天调节性淋巴细胞，能够指导免疫和炎症反应对脓毒症。iNKT 细胞的重复刺激导致无能的诱导与 CD3 iNKT 细胞亚群的出现。
从患有脓毒症的危重病手术患者中分离 iNKT 细胞，并对其 CD3 表达进行表型分析。这与疾病严重程度（以 APACHE-II 评分表示）相关。
与健康志愿者相比，重症脓毒症患者中，循环 CD3-iNKT 细胞群的频率随脓毒症严重程度的增加而增加。
CD3-iNKT 细胞的出现可能是脓毒症诱导的免疫功能障碍程度的临床可转化标志物。
