Moufarrej Mira N, Winn Virginia D, Quake Stephen R
Department of Biology, Stanford, CA, USA.
Department of Obstetrics and Gynecology, Stanford, CA, USA.
Curr Hypertens Rep. 2024 Apr;26(4):175-182. doi: 10.1007/s11906-023-01291-z. Epub 2023 Dec 26.
This review summarizes the potential of cell-free nucleic acids for predicting preeclampsia, contrasts them with other methods, and discusses these findings' relevance to preeclampsia's pathogenesis and care.
Recent studies have demonstrated the utility of cell-free nucleic acids in early preeclampsia risk prediction. Encouragingly, nucleic acid measurement exhibits similar or better sensitivity as compared to standard screening assays and furthermore sheds light on preeclampsia's underlying placental biology. Over the past decade, liquid biopsies measuring cell-free nucleic acids have found diverse applications, including in prenatal care. Recent advances have extended their utility to predict preeclampsia, a major cause of maternal mortality. These assays assess methylation patterns in cell-free DNA (cfDNA) or gene levels in cell-free RNA (cfRNA). Currently, preeclampsia care focuses on blood pressure control, seizure prevention, and delivery. If validated, early prediction of preeclampsia through liquid biopsies can improve maternal health and deepen our understanding of its causes.
本综述总结了游离核酸在预测子痫前期方面的潜力，将其与其他方法进行对比，并讨论这些发现与子痫前期发病机制及护理的相关性。
近期研究已证明游离核酸在子痫前期早期风险预测中的作用。令人鼓舞的是，与标准筛查检测相比，核酸检测表现出相似或更高的灵敏度，并且进一步揭示了子痫前期潜在的胎盘生物学特性。在过去十年中，检测游离核酸的液体活检已得到广泛应用，包括在产前护理中。最近的进展将其应用扩展至预测子痫前期，子痫前期是孕产妇死亡的主要原因。这些检测评估游离DNA（cfDNA）中的甲基化模式或游离RNA（cfRNA）中的基因水平。目前，子痫前期护理主要集中在血压控制、预防癫痫发作和分娩。如果得到验证，通过液体活检对子痫前期进行早期预测可改善孕产妇健康，并加深我们对其病因的理解。
