lncRNA LINC01018通过调控miR-182-5p在前列腺癌中的预后价值（LINC01018在前列腺癌中的作用）
Prognostic value of lncRNA LINC01018 in prostate cancer by regulating miR-182-5p (The role of LINC01018 in prostate cancer).
作者信息
Luo Wentao, Li Tingting, Song Qiong, Zhang Lixiao, Cao Min
机构信息
Department of Urology Andrology, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2024;43(10):1077-1089. doi: 10.1080/15257770.2023.2298408. Epub 2023 Dec 26.
LncRNAs are abnormally expressed in a variety of cancers and play unique roles in therapy. Based on this, the prognostic value of lncRNA LINC01018 in prostate cancer was discussed in this study. LINC01018 was underexpressed in prostate cancer tissues and cells, while miR-182-5p was elevated (*** < 0.001). Overexpression of LINC01018 may inhibit the progression of prostate cancer by targeting miR-182-5p. This study revealed that upregulated LINC01018 may prolong the overall survival of patients with prostate cancer (log-rank = 0.042), and LINC01018 may become a prognostic biomarker for patients with prostate cancer, which brings a new direction for the treatment of patients.
长链非编码RNA（lncRNAs）在多种癌症中异常表达，并在治疗中发挥独特作用。基于此，本研究探讨了lncRNA LINC01018在前列腺癌中的预后价值。LINC01018在前列腺癌组织和细胞中表达下调，而miR-182-5p表达升高（*** < 0.001）。LINC01018的过表达可能通过靶向miR-182-5p抑制前列腺癌的进展。本研究表明，上调LINC01018可能延长前列腺癌患者的总生存期（对数秩检验 = 0.042），且LINC01018可能成为前列腺癌患者的预后生物标志物，这为患者的治疗带来了新方向。
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