镍催化溴代环丁烯的立体汇聚还原二聚反应。
Ni-Catalyzed Stereoconvergent Reductive Dimerization of Bromocyclobutenes.
作者信息
Spieß Philipp, Matheu Sergio Armentia, Bauer Adriano, Coussanes Guilhem, Shaaban Saad, Maulide Nuno
机构信息
Institute of Organic Chemistry, University of Vienna, Währinger Straße 38, 1090 Vienna, Austria.
出版信息
Org Lett. 2024 Jan 12;26(1):355-359. doi: 10.1021/acs.orglett.3c03909. Epub 2023 Dec 26.
A nickel-catalyzed reductive dimerization of bromocyclobutenes to produce unusual and unprecedented cyclobutene dimers was developed. In a stereoconvergent procedure, various bromocyclobutenes were readily dimerized in good yields, with good diastereoselectivities and broad functional group tolerance. Notably, the presence of a carbonyl group in the starting material appears to dictate diastereoselectivity.
开发了一种镍催化的溴代环丁烯还原二聚反应，以制备不寻常且前所未有的环丁烯二聚体。在立体汇聚过程中，各种溴代环丁烯很容易以良好的产率进行二聚反应，具有良好的非对映选择性和广泛的官能团耐受性。值得注意的是，起始原料中羰基的存在似乎决定了非对映选择性。
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