不同麻醉剂对磷酸二鲸蜡酯囊泡渗透作用的研究。

A study of the permeation of dihexadecyl phosphate vesicles by various anesthetics.

作者信息

Ménassa P E, Sandorfy C

出版信息

Biophys Chem. 1986 Dec 15;25(2):175-9. doi: 10.1016/0301-4622(86)87008-9.

Abstract

A simple spectroscopic method for the evaluation of the effect that perturbers may have on a membrane model is described. The model was made from dihexadecyl phosphate (DHP) bilayers. The perturbers used were unconventional anesthetics (n-alcohols C1-C8; n-hexane and n-pentane) and conventional anesthetics (chloroform, methoxyflurane, halothane and enflurane). The results show a correlation between vesicle permeation by anesthetics and their clinical potency. Two modes of perturbation by which the anesthetics may induce vesicle permeation are proposed.

摘要

描述了一种用于评估干扰物对膜模型可能产生的影响的简单光谱方法。该模型由磷酸二己酯（DHP）双层制成。所使用的干扰物是非常规麻醉剂（正构醇C1 - C8；正己烷和正戊烷）和常规麻醉剂（氯仿、甲氧氟烷、氟烷和恩氟烷）。结果表明麻醉剂引起的囊泡渗透与其临床效力之间存在相关性。提出了麻醉剂可能诱导囊泡渗透的两种干扰模式。