DNA酶I对肌原肌球蛋白聚合的抑制作用。

Inhibition of muscle tropomyosin polymerization by DNAse I.

作者信息

Payne M R, Rudnick S E

出版信息

Biosci Rep. 1986 Aug;6(8):721-6. doi: 10.1007/BF01116539.

Abstract

Tropomyosin polymerization is inhibited by DNAse I, an endonuclease which also interacts with G-actin. A 1:4 molar ratio of DNAse I to adult chicken pectoralis muscle tropomyosin almost completely prevents the increased viscosity of tropomyosin under polymerizing ionic conditions. While G-actin binding to DNAse I inhibits the DNAse I hydrolysis of DNA, tropomyosin does not affect this enzymatic activity. G-actin-DNAse I interaction is also not altered by tropomyosin.

摘要

原肌球蛋白的聚合受到脱氧核糖核酸酶I（一种也与球形肌动蛋白相互作用的核酸内切酶）的抑制。脱氧核糖核酸酶I与成年鸡胸肌原肌球蛋白的摩尔比为1:4时，几乎能完全阻止在聚合离子条件下原肌球蛋白粘度的增加。虽然球形肌动蛋白与脱氧核糖核酸酶I的结合会抑制脱氧核糖核酸酶I对DNA的水解，但原肌球蛋白不会影响这种酶活性。原肌球蛋白也不会改变球形肌动蛋白与脱氧核糖核酸酶I的相互作用。