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2019年冠状病毒病疫情对新加坡造血干细胞移植项目的影响。

Impact of the COVID-19 pandemic on hematopoietic stem cell transplant programmes in Singapore.

作者信息

Jia Rong Timothy Lam, Basker Gayathri, Yong Hoe Chan, Hein Than, Poon Li Mei Michelle, Yeow Tee Goh

机构信息

Asian Medical Student Association Singapore SGMarrow Research Committee, Singapore.

Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

出版信息

Blood Cell Ther. 2023 Nov 25;6(4):139-144. doi: 10.31547/bct-2023-019.

Abstract

BACKGROUND

Hematopoietic stem cell transplantation (HSCT) has been performed in Singapore since 1985. Currently, more than 100 transplants are performed annually across the public and private sectors. In 2020, the COVID-19 pandemic resulted in unprecedented disruptions to global healthcare systems, and Singapore was no exception. In particular, the field of HSCT faced additional, unique challenges aside from those borne by the healthcare system at large, and appropriate measures were necessary to ensure that HSCT remained available to patients who needed it.

METHODS

The expert opinions of six hematologists from various institutions across Singapore were gathered through individual interviews and summarized. This was supplemented by a literature review on bone marrow donation and HSCT in Singapore.

MAIN FINDINGS AND CONCLUSION

In Singapore, the COVID-19 pandemic has had significant implications for HSCT, ranging from the implementation of additional infection control measures in hospitals to an accelerated rise in haploidentical transplants. Further research is required to better understand and quantify these impacts, improve existing processes, and investigate the effects of COVID-19 and its treatment modalities on patients with HSCT.

摘要

背景

自1985年以来,新加坡一直在开展造血干细胞移植(HSCT)。目前,公共和私营部门每年进行100多例移植手术。2020年,新冠疫情给全球医疗系统带来了前所未有的破坏,新加坡也不例外。特别是,造血干细胞移植领域除了面临整个医疗系统所面临的挑战外,还面临着其他独特的挑战,因此需要采取适当措施,以确保有需要的患者能够继续接受造血干细胞移植。

方法

通过个人访谈收集了新加坡各机构六名血液学家的专家意见并进行了总结。此外,还对新加坡的骨髓捐赠和造血干细胞移植进行了文献综述。

主要发现与结论

在新加坡,新冠疫情对造血干细胞移植产生了重大影响,从医院实施额外的感染控制措施到单倍体移植的加速增长。需要进一步研究,以更好地理解和量化这些影响、改进现有流程,并调查新冠病毒及其治疗方式对造血干细胞移植患者的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ef3/10749730/34a4cef7320f/2432-7026-6-4-0139-g001.jpg

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引用本文的文献

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Ann Med Surg (Lond). 2024 Aug 7;86(9):5416-5424. doi: 10.1097/MS9.0000000000002442. eCollection 2024 Sep.

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Impact of COVID-19 in hematopoietic stem cell transplant recipients: A systematic review and meta-analysis.
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