交感神经系统在雌激素诱导的大鼠高血压中的作用。
The role of the sympathetic nervous system in oestrogen-induced hypertension in rats.
作者信息
Bhatt J D, Gulati O D
出版信息
Br J Pharmacol. 1986 Dec;89(4):685-91. doi: 10.1111/j.1476-5381.1986.tb11172.x.
Albino rats of either sex received chronic ethinyl oestradiol (EO) treatment (1.5 mg kg-1 daily, i.m.) for 3 weeks. Untreated control rats received arachis oil vehicle alone. Chronic EO treatment resulted in elevation of blood pressure in both sexes. Female rats exhibited significantly greater elevation in blood pressure than males. In chronic EO-treated rats pressor responses to low doses (0.5 micrograms kg-1) of noradrenaline were significantly increased, while those to angiotensin II, acetylcholine and isoprenaline were unaltered. Chronic EO treatment also sensitized the vascular bed of the rats' hindquarters to noradrenaline. EO-induced hypertension was associated with significant increase in dopamine-beta-hydroxylase activity of adrenal glands. Complete bilateral adrenalectomy or chemical sympathectomy prevented the development of EO-induced hypertension. It is suggested that chronic treatment of rats with EO induces and maintains hypertension. The peripheral sympathetic system plays an important role in this phenomenon.
对雌雄白化大鼠进行为期3周的炔雌醇（EO）慢性治疗（每日1.5毫克/千克，肌肉注射）。未治疗的对照大鼠仅接受花生油载体。慢性EO治疗导致两性血压升高。雌性大鼠的血压升高明显高于雄性。在慢性EO治疗的大鼠中，对低剂量（0.5微克/千克）去甲肾上腺素的升压反应显著增加，而对血管紧张素II、乙酰胆碱和异丙肾上腺素的反应未改变。慢性EO治疗还使大鼠后肢血管床对去甲肾上腺素敏感。EO诱导的高血压与肾上腺多巴胺-β-羟化酶活性显著增加有关。双侧肾上腺完全切除或化学性交感神经切除可预防EO诱导的高血压的发生。提示对大鼠进行EO慢性治疗可诱导并维持高血压。外周交感神经系统在这一现象中起重要作用。
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