犬和猫肾上腺髓质对反射性刺激和拟胆碱药反应中的毒蕈碱和烟碱机制
Muscarinic and nicotinic mechanisms in the responses of the adrenal medulla of the dog and cat to reflex stimuli and to cholinomimetic drugs.
作者信息
Critchley J A, Ellis P, Henderson C G, Ungar A, West C P
出版信息
Br J Pharmacol. 1986 Dec;89(4):831-5. doi: 10.1111/j.1476-5381.1986.tb11188.x.
Abstract
In isolated perfused adrenal glands of the cat, muscarinic and nicotinic agonists selectively released adrenaline and noradrenaline respectively. In isolated perfused adrenal glands of the dog, the output of adrenaline and noradrenaline remained in a fixed ratio at rest and when stimulated by muscarinic or by nicotinic agonists. In the anaesthetized dog, a combination of muscarinic and nicotinic antagonists was needed to block reflex responses of the adrenal medulla. A nicotinic antagonist was more effective in blocking the baroreceptor reflex response than the chemoreceptor reflex response.
摘要
在猫的离体灌注肾上腺中，毒蕈碱激动剂和烟碱激动剂分别选择性地释放肾上腺素和去甲肾上腺素。在狗的离体灌注肾上腺中，肾上腺素和去甲肾上腺素的输出在静息时以及受到毒蕈碱或烟碱激动剂刺激时保持固定比例。在麻醉的狗中，需要联合使用毒蕈碱拮抗剂和烟碱拮抗剂来阻断肾上腺髓质的反射反应。烟碱拮抗剂在阻断压力感受器反射反应方面比化学感受器反射反应更有效。
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The reflex release of adrenaline and noradrenaline from the adrenal glands of cats and dogs.猫和狗肾上腺中肾上腺素和去甲肾上腺素的反射性释放。
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Nature. 1965 Dec 11;208(5015):1102-3. doi: 10.1038/2081102a0.
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Effect of cholinergic antagonists on sympathetic ganglionic transmission of vasomotor reflexes from the carotid baroreceptors and chemoreceptors of the dog.胆碱能拮抗剂对犬颈动脉压力感受器和化学感受器血管运动反射的交感神经节传递的影响。
J Physiol. 1978 Apr;277:379-85. doi: 10.1113/jphysiol.1978.sp012278.
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