Critchley J A, Ellis P, Henderson C G, Ungar A, West C P
Br J Pharmacol. 1986 Dec;89(4):831-5. doi: 10.1111/j.1476-5381.1986.tb11188.x.
In isolated perfused adrenal glands of the cat, muscarinic and nicotinic agonists selectively released adrenaline and noradrenaline respectively. In isolated perfused adrenal glands of the dog, the output of adrenaline and noradrenaline remained in a fixed ratio at rest and when stimulated by muscarinic or by nicotinic agonists. In the anaesthetized dog, a combination of muscarinic and nicotinic antagonists was needed to block reflex responses of the adrenal medulla. A nicotinic antagonist was more effective in blocking the baroreceptor reflex response than the chemoreceptor reflex response.
在猫的离体灌注肾上腺中,毒蕈碱激动剂和烟碱激动剂分别选择性地释放肾上腺素和去甲肾上腺素。在狗的离体灌注肾上腺中,肾上腺素和去甲肾上腺素的输出在静息时以及受到毒蕈碱或烟碱激动剂刺激时保持固定比例。在麻醉的狗中,需要联合使用毒蕈碱拮抗剂和烟碱拮抗剂来阻断肾上腺髓质的反射反应。烟碱拮抗剂在阻断压力感受器反射反应方面比化学感受器反射反应更有效。