垂体 - 肾上腺皮质轴在犬肾上腺髓质反射反应中的作用。
The role of the pituitary-adrenocortical axis in reflex responses of the adrenal medulla of the dog.
作者信息
Critchley J A, Ellis P, Henderson C G, Ungar A
出版信息
J Physiol. 1982 Feb;323:533-41. doi: 10.1113/jphysiol.1982.sp014090.
Abstract
- The release of catecholamines from the adrenal medulla, in response to carotid body hypoxia, may outlast the stimulus by more than 30 min. 2. After denervation of the adrenal gland the immediate release of catecholamines in response to carotid hypoxia is abolished, but the prolonged release remains. 3. The prolonged release of catecholamines is abolished by cycloheximide. 4. Both corticotrophin in vivo and hydrocortisone in the isolated perfused adrenal gland release adrenomedullary catecholamines. 5. It is concluded that a component of the response of the adrenal medulla to carotid body hypoxia is mediated by corticotrophin and corticosteroid release.
摘要
- 作为对颈动脉体缺氧的反应，肾上腺髓质释放儿茶酚胺的时间可能比刺激持续时间长30多分钟。2. 肾上腺去神经支配后，对颈动脉缺氧的即时儿茶酚胺释放被消除，但延长释放仍存在。3. 环己酰亚胺可消除儿茶酚胺的延长释放。4. 体内促肾上腺皮质激素和离体灌注肾上腺中的氢化可的松均可释放肾上腺髓质儿茶酚胺。5. 得出的结论是，肾上腺髓质对颈动脉体缺氧反应的一个组成部分是由促肾上腺皮质激素和皮质类固醇释放介导的。
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