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胃癌的一种潜在治疗方法：抑制 LACTB 转录本 1。

A potential therapeutic approach for gastric cancer: inhibition of LACTB transcript 1.

机构信息

Center of Clinical Laboratories, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.

Department of Basic Clinical Laboratory and Hematology, School of Clinical Laboratory Science, Guizhou Medical University, Guiyang, China.

出版信息

Aging (Albany NY). 2023 Dec 26;15(24):15213-15227. doi: 10.18632/aging.205345.

DOI:10.18632/aging.205345
PMID:38149985
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10781463/
Abstract

BACKGROUND

This study sought to investigate the role of LACTB transcript 1 in regulating adaptive immune resistance and stemness in gastric cancer and its potential as a therapeutic target for precision medicine.

METHODS

Bioinformatics analysis and RT-qPCR were used to analyze the expression level of LACTB and its transcripts in gastric cancer cells. The effects of LACTB transcript 1 on adaptive immune resistance and stemness were evaluated using cell experiments and western blotting experiments.

RESULTS

Our study findings revealed that LACTB transcript 1 modulated adaptive immune resistance and inhibited the stemness of gastric cancer cells. Knocking down the expression level of LACTB transcript 1 activated autophagy and inhibited EMT. As expected, overexpression of LACTB transcript 1 yielded the opposite findings. The expression level of LACTB transcript 1 in the peripheral blood of gastric cancer patients was consistent with the bioinformatics analysis, suggesting its potential as a biomarker of gastric cancer.

CONCLUSIONS

LACTB transcript 1 is a promising therapeutic target for precision medicine in gastric cancer by modulating immune evasion mechanisms and stemness. These findings provide insights into leveraging long non-coding RNAs (lncRNAs) in immunotherapy, radiotherapy, and chemotherapy to enhance cancer therapy efficacy, particularly in the context of targeting tumor heterogeneity and stemness.

摘要

背景

本研究旨在探讨 LACTB 转录本 1 在调节胃癌适应性免疫抵抗和干性中的作用及其作为精准医学治疗靶点的潜力。

方法

采用生物信息学分析和 RT-qPCR 分析胃癌细胞中 LACTB 及其转录本的表达水平。通过细胞实验和 Western blot 实验评估 LACTB 转录本 1 对适应性免疫抵抗和干性的影响。

结果

我们的研究结果表明，LACTB 转录本 1 调节适应性免疫抵抗并抑制胃癌细胞的干性。敲低 LACTB 转录本 1 的表达水平激活自噬并抑制 EMT。预期的是，LACTB 转录本 1 的过表达产生了相反的结果。胃癌患者外周血中 LACTB 转录本 1 的表达水平与生物信息学分析一致，表明其可能是胃癌的生物标志物。

结论

LACTB 转录本 1 通过调节免疫逃逸机制和干性，是胃癌精准医学治疗的有前途的靶点。这些发现为利用长链非编码 RNA（lncRNA）在免疫治疗、放疗和化疗中增强癌症治疗效果提供了思路，特别是在靶向肿瘤异质性和干性方面。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/053b/10781463/b2b7f9a4171e/aging-15-205345-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/053b/10781463/11be589659cc/aging-15-205345-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/053b/10781463/2e860a754ce4/aging-15-205345-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/053b/10781463/8c06e19c823d/aging-15-205345-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/053b/10781463/2a054a86d6a2/aging-15-205345-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/053b/10781463/14570cd589cf/aging-15-205345-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/053b/10781463/b2b7f9a4171e/aging-15-205345-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/053b/10781463/11be589659cc/aging-15-205345-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/053b/10781463/2e860a754ce4/aging-15-205345-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/053b/10781463/8c06e19c823d/aging-15-205345-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/053b/10781463/2a054a86d6a2/aging-15-205345-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/053b/10781463/14570cd589cf/aging-15-205345-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/053b/10781463/b2b7f9a4171e/aging-15-205345-g006.jpg

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2
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Cell Death Dis. 2022 Jan 13;13(1):56. doi: 10.1038/s41419-021-04364-6.
3
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Int J Mol Sci. 2021 Dec 15;22(24):13455. doi: 10.3390/ijms222413455.
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6
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