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新型药物筛选检测方法研究 和 碳酸酐酶抑制剂的抗阿米巴作用。

Novel Drug Screening Assay for and the Anti-Amoebic Effect of Carbonic Anhydrase Inhibitors.

机构信息

Faculty of Medicine and Health Technology, Tampere University, FI-33520 Tampere, Finland.

Fimlab Ltd, Tampere University Hospital, FI-33520 Tampere, Finland.

出版信息

J Med Chem. 2024 Jan 11;67(1):152-164. doi: 10.1021/acs.jmedchem.3c01020. Epub 2023 Dec 27.

DOI:10.1021/acs.jmedchem.3c01020
PMID:38150360
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10788897/
Abstract

is an amoeba that inhabits soil and water in every part of the world. Acanthamoeba infection of the eye causes keratitis and can lead to a loss of vision. Current treatment options are only moderately effective, have multiple harmful side effects, and are tedious. In our study, we developed a novel drug screening method to define the inhibitory properties of potential new drugs against in vitro. We found that the clinically used carbonic anhydrase inhibitors, acetazolamide, ethoxzolamide, and dorzolamide, have promising antiamoebic properties.

摘要

棘阿米巴原虫是一种存在于世界各地土壤和水中的变形虫。棘阿米巴角膜炎可引起角膜炎症，并导致视力丧失。目前的治疗选择效果仅为中等，有多种有害的副作用，而且繁琐。在我们的研究中，我们开发了一种新的药物筛选方法，以确定潜在新药对体外的抑制特性。我们发现，临床上使用的碳酸酐酶抑制剂，乙酰唑胺、依索唑胺和多佐胺，具有有前途的抗阿米巴特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d696/10788897/d71bd5cc73bb/jm3c01020_0009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d696/10788897/e7f39f816bc9/jm3c01020_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d696/10788897/148e27344ac9/jm3c01020_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d696/10788897/d6dd324dc14c/jm3c01020_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d696/10788897/77fe5fb67c08/jm3c01020_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d696/10788897/d71bd5cc73bb/jm3c01020_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d696/10788897/e38f75cef276/jm3c01020_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d696/10788897/81f6716c94ec/jm3c01020_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d696/10788897/33c2db729de2/jm3c01020_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d696/10788897/0067398e2c5b/jm3c01020_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d696/10788897/e7f39f816bc9/jm3c01020_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d696/10788897/148e27344ac9/jm3c01020_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d696/10788897/d6dd324dc14c/jm3c01020_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d696/10788897/77fe5fb67c08/jm3c01020_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d696/10788897/d71bd5cc73bb/jm3c01020_0009.jpg

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