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卡培他滨诱发获得性掌跖角化病1例罕见病例

A Rare Case on Capecitabine Induced Acquired Palmoplantar Keratoderma.

作者信息

Tsaqilah Laila, Mudia Keshia Amalia Mivina, Usman Hermin Aminah, Dharmadji Hartati Purbo, Hidayah Risa Miliawati Nurul, Avriyanti Erda

机构信息

Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.

Department of Anatomical Pathology, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.

出版信息

Clin Cosmet Investig Dermatol. 2023 Dec 23;16:3713-3718. doi: 10.2147/CCID.S442194. eCollection 2023.

DOI:10.2147/CCID.S442194
PMID:38152152
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10752034/
Abstract

Acquired palmoplantar keratoderma (PPK) is a non-hereditary hyperkeratosis of the palms and soles that is caused by various factors, including chemotherapeutic agents. The purpose of this case report is to present a rare case of acquired PPK caused by the chemotherapeutic agent capecitabine. A 54-year-old female complained of painful erythematous plaques on her palms and soles with history of consuming capecitabine. Physical examination revealed scaly erythematous plaques on the palmoplantar surface and knuckle pads on both hands. Histopathological features showed hyperkeratosis, acanthosis, vasodilatation, and perivascular lymphocytic infiltration. Therefore, the patient was diagnosed with acquired PPK due to capecitabine. The dose of capecitabine was reduced and the patient was administered topical corticosteroid and emollient. Improvement of skin lesions was strongly observed after discontinuation of capecitabine. The underlying cause of PPK should be identified to determine the appropriate treatment. Dose reduction or drug discontinuation is the mainstay therapy for patients with acquired PPK caused by chemotherapeutic agents.

摘要

获得性掌跖角化病(PPK)是一种由多种因素引起的手掌和足底非遗传性角化过度,这些因素包括化疗药物。本病例报告的目的是介绍一例由化疗药物卡培他滨引起的罕见获得性PPK病例。一名54岁女性主诉手掌和足底出现疼痛性红斑斑块,有服用卡培他滨的病史。体格检查发现掌跖表面有鳞屑性红斑斑块,双手有指节垫。组织病理学特征显示角化过度、棘层肥厚、血管扩张和血管周围淋巴细胞浸润。因此,该患者被诊断为卡培他滨所致的获得性PPK。卡培他滨剂量减少,并给予患者外用糖皮质激素和润肤剂。停用卡培他滨后,皮肤病变明显改善。应确定PPK的潜在病因以确定适当的治疗方法。对于化疗药物引起的获得性PPK患者,减少剂量或停药是主要治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f820/10752034/58ea0ed97974/CCID-16-3713-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f820/10752034/ae29fada9937/CCID-16-3713-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f820/10752034/07a7c7d6b414/CCID-16-3713-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f820/10752034/58ea0ed97974/CCID-16-3713-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f820/10752034/ae29fada9937/CCID-16-3713-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f820/10752034/07a7c7d6b414/CCID-16-3713-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f820/10752034/58ea0ed97974/CCID-16-3713-g0003.jpg

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本文引用的文献

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Capecitabine-induced lichenoid drug eruption: a case report.卡培他滨诱发的苔藓样药疹:一例报告
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Palmoplantar keratoderma (PPK): acquired and genetic causes of a not so rare disease.掌跖角化病(PPK):一种并不罕见的疾病的后天性和遗传性病因。
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Phase II study of concurrent capecitabine and external beam radiotherapy for pain control of bone metastases of breast cancer origin.同期卡培他滨和外照射放疗治疗乳腺癌骨转移疼痛的 II 期研究。
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Capecitabine-induced stomatitis: a likely pathogenetic mechanism of oral lichenoid mucositis.卡培他滨引起的口腔炎:口腔苔藓样黏膜炎可能的发病机制。
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Acquired palmoplantar keratoderma.获得性掌跖角化病。
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