Gehlhausen Jeff R, Strausburg Matthew B, Aouthmany Mouhammad, Katona Terrence M, Turner Matthew J
Richard L. Roudebush VA Medical Center, Indianapolis, Indiana.
Dermatol Online J. 2017 Feb 15;23(2):13030/qt75n8m2zq.
Capecitabine is a 5-fluorouracil basedchemotherapeutic drug widely used in the treatmentof solid tumors, especially colorectal and breast. Someof the most common side effects of capecitabine arecutaneous in nature, including hand-foot syndrome(palmar-plantar erythrodysesthesia). Several reports inthe literature link capecitabine use with photosensitivelichenoid eruptions. Herein, we present a case ofcapecitabine-induced lichenoid eruption in an elderlyfemale with metastatic breast cancer and discuss ourfindings in relationship to previously reported cases ofthis and other capecitabine-induced skin pathologies.
卡培他滨是一种基于5-氟尿嘧啶的化疗药物，广泛用于实体瘤的治疗，尤其是结直肠癌和乳腺癌。卡培他滨一些最常见的副作用本质上是皮肤性的，包括手足综合征（掌跖红斑感觉异常）。文献中的几份报告将卡培他滨的使用与光敏性苔藓样疹联系起来。在此，我们报告一例老年转移性乳腺癌女性患者发生卡培他滨诱发的苔藓样疹的病例，并结合此前报道的该病例及其他卡培他滨诱发的皮肤病变病例讨论我们的发现。
