How Kang Nien, Ho Wen Chung, Sundaran Meroshini, Wan Ahmal Kammal Wan Syazween Lyana, Lim Poh Ying, Chew Wilson
Dermatology Unit, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
Hospital Sultan Abdul Aziz Shah, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
Clin Cosmet Investig Dermatol. 2023 Dec 23;16:3719-3729. doi: 10.2147/CCID.S422898. eCollection 2023.
We aim to evaluate the effectiveness and tolerability of a sunscreen formulation containing licochalcone A (LicA) and L-carnitine (LC) as an adjuvant to adapalene in the management of acne and post-acne pigmentation (PAH).
A randomized, double-blind, active comparator-controlled trial of 51 patients aged 18 years or older with a clinical diagnosis of mild-to-moderate acne vulgaris was conducted at the Hospital Sultan Abdul Aziz Shah, Universiti Putra Malaysia. The efficacy and tolerability of once-daily adapalene 1.0% were assessed during the 2-week run-in period. Subsequently, patients were randomized to receive either an add-on investigational LicA-containing sunscreen or niacinamide-containing comparator sunscreen every 4 hourly during daytime for 4 weeks. Patients were followed up at Weeks 2 and 4 to assess for improvement in acne severity, PAH, calorimetric parameters and cutaneous tolerability.
Two weeks of adapalene usage significantly improved acne severity; however, up to 52% of patients experienced dryness, burning and stinging. Adding LicA-containing or comparator sunscreens was associated with further improvement in acne severity, PAH and calorimetric parameters at the study endpoint. No significant differences in the cutaneous tolerability profiles were observed between treatment groups. Notably, significantly fewer patients receiving LicA-containing sunscreen developed scaliness at Week 4 compared with those in the comparator group. In addition, more patients receiving LicA-containing sunscreen reported less dryness, burning and stinging reactions than the comparator group. Importantly, more patients receiving LicA-containing sunscreen agreed that their treatment led to excellent improvement than the comparator group; of note, one patient reported that their condition worsened with the receipt of the comparator product.
The concurrent use of LicA-containing sunscreen with adapalene may improve the cutaneous tolerance to adapalene among Malaysian patients.
我们旨在评估一种含有光甘草定A（LicA）和L-肉碱（LC）的防晒配方作为阿达帕林辅助剂在治疗痤疮和痤疮后色素沉着（PAH）中的有效性和耐受性。
在马来西亚博特拉大学苏丹阿卜杜勒·阿齐兹·沙阿医院对51名年龄在18岁及以上、临床诊断为轻度至中度寻常痤疮的患者进行了一项随机、双盲、活性对照试验。在为期2周的导入期评估每日一次1.0%阿达帕林的疗效和耐受性。随后，患者被随机分为两组，在白天每4小时接受一次含LicA的研究用防晒霜或含烟酰胺的对照防晒霜，持续4周。在第2周和第4周对患者进行随访，以评估痤疮严重程度、PAH、色度参数和皮肤耐受性的改善情况。
使用两周阿达帕林可显著改善痤疮严重程度；然而，高达52%的患者出现干燥、灼烧和刺痛感。在研究终点，添加含LicA的防晒霜或对照防晒霜与痤疮严重程度、PAH和色度参数的进一步改善相关。治疗组之间在皮肤耐受性方面未观察到显著差异。值得注意的是，与对照组相比，在第4周接受含LicA防晒霜的患者出现脱屑的人数明显更少。此外，与对照组相比，接受含LicA防晒霜的患者报告干燥、灼烧和刺痛反应较少的人数更多。重要地是，与对照组相比，接受含LicA防晒霜的患者中更多人认为他们的治疗带来了极佳的改善；值得注意的是，有一名患者报告使用对照产品后病情恶化。
含LicA的防晒霜与阿达帕林同时使用可能会提高马来西亚患者对阿达帕林的皮肤耐受性。
