Nielsen M, Christensen L, Andersen J
Cancer. 1987 Mar 1;59(5):1019-25. doi: 10.1002/1097-0142(19870301)59:5<1019::aid-cncr2820590528>3.0.co;2-n.
In 84 consecutive autopsies of women with a clinical diagnosis of invasive breast cancer, radial scars were found in the contralateral breast in 35 cases (42%) by an extensive histopathologic method. Four women had radial scars on the ipsilateral side in the breast tissue available from the primary surgical procedure or at autopsy. One woman had an invasive breast cancer with morphologic features compatible with but not diagnostic of transition from a radial scar. Of the six radial scars with carcinoma in situ occurring in three women, three were of ductal and three of lobular type. In the remaining cases only radial scars with a benign appearance were found except for two with atypical hyperplasia. The frequency of radial scars was significantly higher in women with fibrocystic disease (55%) compared to women without (24%). Contralateral primary invasive and in situ breast cancer occurred in 68%. No difference in the frequency of radial scars in women with and without breast cancer was found and radial scars were not associated with any specific type of breast cancer. Our findings do not indicate a higher malignant potential of radial scars than of fibrocystic disease. It is suggested that only radial scars containing high-risk epithelial changes such as atypical hyperplasia and carcinoma in situ are associated with an increased risk of subsequent breast cancer development.
在84例临床诊断为浸润性乳腺癌的女性尸检中，通过广泛的组织病理学方法，在35例（42%）对侧乳房中发现了放射状瘢痕。4名女性在初次手术或尸检获得的乳房组织同侧有放射状瘢痕。1名女性患有浸润性乳腺癌，其形态学特征与放射状瘢痕转变相符但不能确诊。在3名女性出现的6例伴有原位癌的放射状瘢痕中，3例为导管型，3例为小叶型。在其余病例中，除2例伴有非典型增生外，仅发现外观良性的放射状瘢痕。与无纤维囊性疾病的女性（24%）相比，患有纤维囊性疾病的女性放射状瘢痕的发生率显著更高（55%）。对侧原发性浸润性和原位乳腺癌的发生率为68%。未发现患癌和未患癌女性放射状瘢痕发生率的差异，且放射状瘢痕与任何特定类型的乳腺癌均无关联。我们的研究结果并未表明放射状瘢痕的恶性潜能高于纤维囊性疾病。提示仅含有非典型增生和原位癌等高风险上皮改变的放射状瘢痕与随后发生乳腺癌的风险增加相关。
