Dyess C L, Carter D, Kirchner J A, Baron R E
Cancer. 1987 Mar 15;59(6):1117-22. doi: 10.1002/1097-0142(19870315)59:6<1117::aid-cncr2820590613>3.0.co;2-p.
Patterns of cartilage invasion by squamous carcinoma were examined in 40 laryngectomy specimens with particular reference to selective involvement of ossified cartilage. The study determines whether external radiation administered at therapeutic levels to the human larynx has selective effects on the osteoclast cell population and subsequent bone resorption. Radiated and nonirradiated tissues were compared as were cases with and without laryngeal framework involvement by cancer. Morphologic changes in ossified laryngeal cartilage showed that invasion is a largely indirect process dominated by local bone destruction with osteoclasts operating in front of the advancing tumor. Morphometric studies indicate that framework invasion correlates significantly with both increased numbers of osteoclasts and increased bone resorption. An original finding here was that radiation therapy resulted in similarly increased osteoclast activity among cases without framework involvement by cancer. In these cases radiation appeared to act independently of tumor in producing osteoclast activation.
在40份喉切除术标本中检查了鳞状细胞癌侵犯软骨的模式，特别关注骨化软骨的选择性受累情况。该研究确定，以治疗剂量对人喉部进行的外照射是否对破骨细胞群体及随后的骨吸收有选择性作用。对接受放疗和未接受放疗的组织进行了比较，同时也比较了有和没有癌侵犯喉支架的病例。骨化喉软骨的形态学变化表明，侵犯在很大程度上是一个间接过程，主要由局部骨破坏主导，破骨细胞在肿瘤进展前沿发挥作用。形态计量学研究表明，支架侵犯与破骨细胞数量增加和骨吸收增加均显著相关。此处一项新发现是，在没有癌侵犯支架的病例中，放射治疗同样导致破骨细胞活性增加。在这些病例中，放射似乎在产生破骨细胞激活方面独立于肿瘤起作用。
