Carter R L, Tanner N S
Clin Otolaryngol Allied Sci. 1979 Aug;4(4):283-90. doi: 10.1111/j.1365-2273.1979.tb01901.x.
Patterns of cartilage invasion by squamous carcinoma were examined in 34 consecutive laryngectomy specimens with particular reference to selective involvement of ossified cartilage. Direct infiltration of the laryngeal framework was demonstrated in 17 cases--16 (out of 17) transglottic carcinomas and in a simgle example of a combined glottic and infraglottic tumour. The susceptibility of ossified laryngeal cartilage to tumour invasion was confirmed, and morphological studies ahve clarified the underlying mechanisms. Invasion is a largely indirect process dominated by local bone destruction by osteoclasts, operating in front of the advancing tumour. One established, carcinoma cells infiltrate and erode bone alone, and the osteoclasts disappear. Reasons for the particular susceptibility of ossified laryngeal cartilage to tumour invasion are discussed and attention is drawn to the role of the tumour-associated osteoclast activating factors such as postaglandins. Therapeutic implications of cartilage invasion are noted.
对34例连续的喉切除标本中鳞状细胞癌侵犯软骨的模式进行了检查，特别关注了骨化软骨的选择性受累情况。17例患者出现了喉支架的直接浸润，其中16例（共17例）为跨声门癌，1例为声门和声门下联合肿瘤。骨化喉软骨对肿瘤侵袭的易感性得到了证实，形态学研究阐明了其潜在机制。侵袭在很大程度上是一个间接过程，主要由破骨细胞在肿瘤前沿进行的局部骨破坏所主导。一旦肿瘤细胞单独浸润并侵蚀骨质，破骨细胞就会消失。讨论了骨化喉软骨对肿瘤侵袭特别易感的原因，并提请注意肿瘤相关破骨细胞激活因子（如前列腺素）的作用。文中还提到了软骨侵袭的治疗意义。
