Gschwendt M, Kittstein W, Marks F
Cancer Lett. 1987 Feb;34(2):187-91. doi: 10.1016/0304-3835(87)90009-7.
The immunosuppressive agent Didemnin B (DB) inhibits biological effects that are induced by topical application of phorbol esters to mouse skin as measured by mouse ear edema and the alkaline phosphatase activity of mouse epidermis. Furthermore, DB suppresses the phosphorylation in vitro of an epidermal cytosolic protein (p100). In these respects DB behaves like CsA, another immunosuppressive compound. Didemnin, however, does not bind to recently described CsA-binding sites.
免疫抑制剂海兔毒素B（DB）可抑制将佛波酯局部涂抹于小鼠皮肤所诱导的生物学效应，这一效应通过小鼠耳部水肿以及小鼠表皮碱性磷酸酶活性来衡量。此外，DB可在体外抑制一种表皮胞质蛋白（p100）的磷酸化。在这些方面，DB的表现与另一种免疫抑制化合物环孢素A（CsA）相似。然而，海兔毒素并不与最近描述的CsA结合位点相结合。
