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心脏异种移植的现状：2023 年 3 月 3 日，德国心脏移植中心在马丁斯里德举办的研讨会报告。

Current Status of Cardiac Xenotransplantation: Report of a Workshop of the German Heart Transplant Centers, Martinsried, March 3, 2023.

机构信息

Herzchirurgische Klinik und Poliklinik, LMU Klinikum, LMU München, Germany.

Klinik für Anaesthesiologie, LMU Klinikum, LMU München, Germany.

出版信息

Thorac Cardiovasc Surg. 2024 Jun;72(4):273-284. doi: 10.1055/a-2235-8854. Epub 2023 Dec 28.

DOI:10.1055/a-2235-8854
PMID:38154473
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11147670/
Abstract

This report comprises the contents of the presentations and following discussions of a workshop of the German Heart Transplant Centers in Martinsried, Germany on cardiac xenotransplantation. The production and current availability of genetically modified donor pigs, preservation techniques during organ harvesting, and immunosuppressive regimens in the recipient are described. Selection criteria for suitable patients and possible solutions to the problem of overgrowth of the xenotransplant are discussed. Obviously microbiological safety for the recipient and close contacts is essential, and ethical considerations to gain public acceptance for clinical applications are addressed. The first clinical trial will be regulated and supervised by the Paul-Ehrlich-Institute as the National Competent Authority for Germany, and the German Heart Transplant Centers agreed to cooperatively select the first patients for cardiac xenotransplantation.

摘要

本报告包含了德国马丁里斯德国心脏移植中心心脏异种移植研讨会的演讲内容和讨论内容。描述了基因修饰供体猪的生产和当前可用性、器官收获过程中的保存技术以及受者的免疫抑制方案。讨论了适合患者的选择标准和解决异种移植过度生长问题的可能方案。显然，受者和密切接触者的微生物安全性至关重要，并且正在考虑获得公众对临床应用的认可的伦理考虑。第一个临床试验将由德国国家主管当局保罗·埃利希研究所（Paul-Ehrlich-Institute）进行监管和监督，德国心脏移植中心同意合作选择第一批心脏异种移植患者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee2/11147670/53c8645552d3/10-1055-a-2235-8854-i0920237024r-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee2/11147670/15358703a696/10-1055-a-2235-8854-i0920237024r-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee2/11147670/e04b1c8bebb7/10-1055-a-2235-8854-i0920237024r-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee2/11147670/82b248a51e56/10-1055-a-2235-8854-i0920237024r-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee2/11147670/53c8645552d3/10-1055-a-2235-8854-i0920237024r-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee2/11147670/15358703a696/10-1055-a-2235-8854-i0920237024r-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee2/11147670/e04b1c8bebb7/10-1055-a-2235-8854-i0920237024r-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee2/11147670/82b248a51e56/10-1055-a-2235-8854-i0920237024r-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee2/11147670/53c8645552d3/10-1055-a-2235-8854-i0920237024r-4.jpg

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