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基于抑制病理性血管生成的中药改善肝纤维化的研究进展

Research progress of traditional Chinese medicine in improving hepatic fibrosis based on inhibiting pathological angiogenesis.

作者信息

Li Zhen, Zhu Junfeng, Ouyang Hao

机构信息

Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

出版信息

Front Pharmacol. 2023 Dec 12;14:1303012. doi: 10.3389/fphar.2023.1303012. eCollection 2023.

Abstract

Hepatic fibrosis is the formation of scar tissue in the liver. This scar tissue replaces healthy liver tissue and can lead to liver dysfunction and failure if left untreated. It is usually caused by chronic liver disease, such as hepatitis B or C, alcohol abuse, or non-alcoholic fatty liver disease. Pathological angiogenesis plays a crucial role in the development of hepatic fibrosis by promoting the growth of new blood vessels in the liver. These new vessels increase blood flow to the damaged areas of the liver, which triggers the activation of hepatic stellate cells (HSCs). HSCs are responsible for producing excess collagen and other extracellular matrix proteins that contribute to the development of fibrosis. Pathological angiogenesis plays a crucial role in the development of hepatic fibrosis by promoting the growth of new blood vessels in the liver. These new vessels increase blood flow to the damaged areas of the liver, which triggers the activation of HSCs. HSCs are responsible for producing excess collagen and other extracellular matrix proteins that contribute to the development of fibrosis. Traditional Chinese medicine (TCM) has been found to target pathological angiogenesis, thereby providing a potential treatment option for hepatic fibrosis. Several studies have demonstrated that TCM exhibits anti-angiogenic effects by inhibiting the production of pro-angiogenic factors, such as vascular endothelial growth factor and angiopoietin-2, and by reducing the proliferation of endothelial cells. Reviewing and highlighting the unique TCM recognition of treating hepatic fibrosis by targeting pathological angiogenesis may shed light on future hepatic fibrosis research.

摘要

肝纤维化是肝脏中瘢痕组织的形成。这种瘢痕组织取代了健康的肝组织,如果不治疗,可能会导致肝功能障碍和衰竭。它通常由慢性肝病引起,如乙型或丙型肝炎、酗酒或非酒精性脂肪性肝病。病理性血管生成通过促进肝脏中新生血管的生长,在肝纤维化的发展中起着关键作用。这些新血管增加了肝脏受损区域的血流量,从而触发肝星状细胞(HSCs)的激活。肝星状细胞负责产生过多的胶原蛋白和其他细胞外基质蛋白,这些蛋白有助于纤维化的发展。病理性血管生成通过促进肝脏中新生血管的生长,在肝纤维化的发展中起着关键作用。这些新血管增加了肝脏受损区域的血流量,从而触发肝星状细胞的激活。肝星状细胞负责产生过多的胶原蛋白和其他细胞外基质蛋白,这些蛋白有助于纤维化的发展。已发现中药靶向病理性血管生成,从而为肝纤维化提供了一种潜在的治疗选择。多项研究表明,中药通过抑制促血管生成因子如血管内皮生长因子和血管生成素-2的产生,以及减少内皮细胞的增殖,表现出抗血管生成作用。回顾并强调中药通过靶向病理性血管生成治疗肝纤维化的独特认识,可能会为未来的肝纤维化研究提供启示。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faa8/10754536/2e0690724e87/fphar-14-1303012-g001.jpg

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