脂代谢、氨基酸代谢与前列腺癌：关键的代谢之旅。
Lipid metabolism, amino acid metabolism, and prostate cancer: a crucial metabolic journey.
机构信息
School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou 311121, China.
出版信息
Asian J Androl. 2024 Mar 1;26(2):123-134. doi: 10.4103/aja202363. Epub 2023 Dec 26.
Prostate cancer (PCa) is one of the most common malignancies in males worldwide, and its development and progression involve the regulation of multiple metabolic pathways. Alterations in lipid metabolism affect the proliferation and metastatic capabilities of PCa cells. Cancer cells increase lipid synthesis and regulate fatty acid oxidation to meet their growth and energy demands. Similarly, changes occur in amino acid metabolism in PCa. Cancer cells exhibit an increased demand for specific amino acids, and they regulate amino acid transport and metabolic pathways to fulfill their proliferation and survival requirements. These changes are closely associated with disease progression and treatment response in PCa cells. Therefore, a comprehensive investigation of the metabolic characteristics of PCa is expected to offer novel insights and approaches for the early diagnosis and treatment of this disease.
前列腺癌（PCa）是全球男性最常见的恶性肿瘤之一，其发生和发展涉及多个代谢途径的调控。脂代谢的改变会影响 PCa 细胞的增殖和转移能力。癌细胞增加脂质合成并调节脂肪酸氧化以满足其生长和能量需求。同样，PCa 中的氨基酸代谢也会发生变化。癌细胞对特定氨基酸的需求增加，它们调节氨基酸的转运和代谢途径以满足其增殖和存活的要求。这些变化与 PCa 细胞的疾病进展和治疗反应密切相关。因此，全面研究 PCa 的代谢特征有望为该疾病的早期诊断和治疗提供新的思路和方法。
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